Rekombinanter IL1R2 Antikörper (Extracellular Domain)

Produktnummer ABIN1169422

Produktdetails anti-IL1R2 Antikörper

Target: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Antikörpertyp: Recombinant Antibody

Bindungsspezifität: Extracellular Domain

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL1R2 Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Spezifität: Recognizes mouse IL-1R2.

Kreuzreaktivität: Maus

Aufreinigung: Purified from HEK 293 cell culture supernatant.

Reinheit: >95 % (SDS-PAGE)

Endotoxin-Niveau: <0.01EU/μg purified protein (LAL-test, Lonza).

Immunogen: Recombinant mouse IL-1R2 (extracellular domain).

Klon: Praxy-1-1

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

IL-1R2 (mouse) monoclonal antibody (recombinant) (Praxy-1-1) is composed of human variable regions (VH and VL) (lambda-chain) of immunoglobulin fused to the mouse IgG2b Fc domain.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 month after receipt when stored at +4°C. Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Details zu IL1R2

Target: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Andere Bezeichnung: IL-1R2 (IL1R2 Produkte)

Synonyme: CD121b antikoerper, CDw121b antikoerper, IL-1R-2 antikoerper, IL-1RT-2 antikoerper, IL-1RT2 antikoerper, IL1R2c antikoerper, IL1RB antikoerper, Il1r-2 antikoerper, IL-1R2 antikoerper, interleukin 1 receptor type 2 antikoerper, interleukin 1 receptor, type II antikoerper, interleukin-like antikoerper, IL1R2 antikoerper, Il1r2 antikoerper, KK34 antikoerper

Hintergrund: The inflammatory actions of IL-1alpha and beta depend on their interaction with its receptor, IL-1R1, and can be negatively controlled by several inhibitors such as IL-1Ra, IL-1R type 2 (IL-1R2), SIGIRR and the soluble form of IL-1 receptor accessory protein (IL-1RAcP). IL-1R2 neutralizes IL-1 either as a surface decoy receptor or in a cleaved and secreted form. IL-1R2 is expressed on B cells, on neutrophils and on in vitro expanded human Tregs.

UniProt: P27931

Pathways: NF-kappaB Signalweg