LTBR Antikörper (Cysteine-Rich Domain)

Produktnummer ABIN1169122

Produktdetails anti-LTBR Antikörper

Target: LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))

Bindungsspezifität: AA 31-221, Cysteine-Rich Domain

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser LTBR Antikörper ist unkonjugiert

Applikation: Functional Studies (Func)

Spezifität: Recognizes mouse LTbetaR.

Kreuzreaktivität: Maus

Aufreinigung: Purified from concentrated hybridoma tissue culture supernatant.

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant mouse LTbetaR (cysteine-rich region) (aa 31-221).

Klon: 3C8

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

The monoclonal antibody to mouse LTbetaR is an agonist that can be used for the investigation of the regulation of BAFF (BlyS), chemokines and integrins using in vivo and tissue culture models, the development of NK cells and NK T cells, to study the regulation of NF-kappaB family of transcription factors in regulation of inflammation and homeostasis, particularly RelB NF-kappaB2 pathway. For use as an agonist the MAb to LTbetaR is added to cell cultures at 2μg/ml. For in vivo use, mice are injected intraperitoneally with 50μg of agonistic MAb to LTbetaR in sterile phosphate saline buffer.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-LTBR Antikörper (ABIN1169122)

Vondenhoff, Greuter, Goverse, Elewaut, Dewint, Ware, Hoorweg, Kraal, Mebius: "LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 9, pp. 5439-45, (2009) (PubMed).

Benedict, De Trez, Schneider, Ha, Patterson, Ware: "Specific remodeling of splenic architecture by cytomegalovirus." in: PLoS pathogens, Vol. 2, Issue 3, pp. e16, (2006) (PubMed).

Banks, Rickert, Benedict, Ma, Ko, Meier, Ha, Schneider, Granger, Turovskaya, Elewaut, Otero, French, Henry, Hamilton, Scheu, Pfeffer, Ware: "A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 11, pp. 7217-25, (2005) (PubMed).

Details zu LTBR

Target: LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))

Andere Bezeichnung: LTbetaR (LTBR Produkte)

Synonyme: AI256028 antikoerper, CD18 antikoerper, LTbetaR antikoerper, Ltar antikoerper, TNF-R-III antikoerper, TNFCR antikoerper, TNFR-RP antikoerper, TNFR2-RP antikoerper, TNFRrp antikoerper, Tnfbr antikoerper, Tnfrsf3 antikoerper, D12S370 antikoerper, LT-BETA-R antikoerper, TNFR3 antikoerper, TNFRSF3 antikoerper, lymphotoxin beta receptor antikoerper, lymphotoxin B receptor antikoerper, Ltbr antikoerper, LTBR antikoerper

Hintergrund: The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

UniProt: P50284

Pathways: NF-kappaB Signalweg