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Endoglin Antikörper (AA 26-581)

ENG Reaktivität: Maus WB, FACS, IHC (fro), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN115701
  • Target Alle Endoglin (ENG) Antikörper anzeigen
    Endoglin (ENG)
    Bindungsspezifität
    • 16
    • 14
    • 12
    • 12
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 26-581
    Reaktivität
    • 178
    • 66
    • 44
    • 17
    • 10
    • 3
    • 2
    • 1
    Maus
    Wirt
    • 106
    • 93
    • 21
    • 1
    • 1
    Kaninchen
    Klonalität
    • 115
    • 106
    • 1
    Polyklonal
    Konjugat
    • 92
    • 28
    • 26
    • 26
    • 15
    • 9
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Endoglin Antikörper ist unkonjugiert
    Applikation
    • 152
    • 133
    • 62
    • 58
    • 37
    • 21
    • 19
    • 15
    • 14
    • 13
    • 13
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
    Aufreinigung
    Antigen affinity chromatography
    Immunogen
    Recombinant mouse soluble CD105/Endoglin. It consists of amino acid 26 (Glu) to 581 (Gly) and is fused to a C-terminal His-tag (6xHis).
    Top Product
    Discover our top product ENG Primärantikörper
  • Applikationshinweise
    ELISA (1 - 15 μg/mL). Western blot (1 - 2 μg/mL). Flow cytometry (3 - 20 μg/mL).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    Reconstitute in sterile water/PBS to a concentration of >0.5 mg/mL
    Buffer
    Immunglobulin fraction in Phosphate buffered saline pH 7.4 without preservative and stabilizer
    Konservierungsmittel
    Without preservative
    Handhabung
    Avoid repeated freeze-thaw cycles. Following reconstitution the antibody is stable for six weeks at 2-8°C.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    The lyophilized IgG is stable at 2-8 °C for one month and for one year from despatch when kept at -20 °C.
    Haltbarkeit
    12 months
  • Target
    Endoglin (ENG)
    Andere Bezeichnung
    CD105 / Endoglin (ENG Produkte)
    Synonyme
    ENG antikoerper, MGC137842 antikoerper, DKFZp469D0419 antikoerper, END antikoerper, HHT1 antikoerper, ORW1 antikoerper, AI528660 antikoerper, AI662476 antikoerper, CD105 antikoerper, S-endoglin antikoerper, endoglin antikoerper, ENG antikoerper, Eng antikoerper
    Hintergrund
    Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human endoglin, the S-endoglin and L-endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse endoglin share approximately 70 % and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart development. Mutations in human endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular disorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.Synonyms: END, ENG, HHT1, ORW, ORW1
    Gen-ID
    10090
    UniProt
    Q63961
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