Endoglin Antikörper (AA 26-581)

Produktnummer ABIN115700

Produktdetails anti-Endoglin Antikörper

Target: Endoglin (ENG)

Bindungsspezifität: AA 26-581

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Endoglin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Aufreinigung: Protein A Chromatography (+his tag depleted)

Immunogen: Highly pure recombinant Mouse soluble CD105 produced in Insect cells. The recombinant soluble CD105 consists of amino acid 26(Glu) to 581 (Gly) and is fused to a C-terminal His-tag (6xHis).

Anwendungsinformationen

Applikationshinweise: ELISA (1-15 μg/mL). Western blot (1-2 μg/mL). Flow Cytometry (3-20 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with sterile water to a concentration of 0.1-1.0 mg/mL

Buffer: PBS, pH 7.2 without preservatives

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. For extended storage add glycerol to 50%.

Details zu Endoglin

Target: Endoglin (ENG)

Andere Bezeichnung: CD105 / Endoglin (ENG Produkte)

Synonyme: ENG antikoerper, MGC137842 antikoerper, DKFZp469D0419 antikoerper, END antikoerper, HHT1 antikoerper, ORW1 antikoerper, AI528660 antikoerper, AI662476 antikoerper, CD105 antikoerper, S-endoglin antikoerper, endoglin antikoerper, ENG antikoerper, Eng antikoerper

Hintergrund: Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human endoglin, the S-endoglin and L-endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse endoglin share approximately 70 % and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart evelopment. Mutations in human endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular isorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.Synonyms: END, ENG, HHT1, ORW, ORW1

Gen-ID: 10090

UniProt: Q63961