MSH6 Antikörper (MutS Homolog 6 (E. Coli))

Details for Product anti-MSH6 Antibody No. ABIN115272, Anbieter: Anmelden zum Anzeigen
Antigen
  • cb326
  • wu:fb36c12
  • LOC100227810
  • GTBP
  • GTMBP
  • HNPCC5
  • HSAP
  • p160
  • AU044881
  • AW550279
  • Gtmbp
  • mutS homolog 6 (E. coli)
  • LOC100360342
  • msh6
  • Msh6
  • MSH6
  • LOC100227810
Reaktivität
Hund, Human, Maus, Ratte (Rattus)
151
50
39
8
7
2
1
1
1
1
1
Wirt
Maus
78
61
12
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser MSH6 Antikörper ist unkonjugiert
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
106
50
46
42
38
13
12
12
9
6
5
4
3
3
2
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Immunogen Synthetic human MSH6 peptide
Klon 44
Isotyp IgG1
Spezifität MSH6 is a heterodimer of MSH2 binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop.
Cellular Localization: Nuclear.
Reinigung Affinity Chromatography.
Andere Bezeichnung MSH6 (MSH6 Antibody Abstract)
Hintergrund An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time.Synonyms: DNA mismatch repair protein Msh6, G/T mismatch-binding protein, GTBP, MutS-alpha 160 kDa subunit, p160
Gen-ID 2956
NCBI Accession NP_000170
UniProt P52701
Forschungsgebiet Chromatin and Nuclear Signaling, DNA/RNA
Pathways DNA Reparatur, Chromatin Binding, Production of Molecular Mediator of Immune Response
Applikationshinweise Immunoprecipitation. Western Blot: 1/100-1/500. Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: 1/25-1/50 in an ABCmethod (30 to 60 minutes at room temperature (requires high temperature antigenunmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining). Immunohistochemistry on Frozen Sections. Recommended Positive Control: Tonsil, colon carcinoma
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-MutS Homolog 6 (E. Coli) (MSH6) antibody (ABIN115272) Formalin fixed paraffin embedded human colon carcinoma stained with MSH6 antibody. AB...
Allgemeine Veröffentlichungen Schleger, Heck, Niketeghad, Schirmacher, Radaeva, Oesch, Dienes, Bannasch, Steinberg: "Establishment and characterization of a nontumorigenic cell line derived from a human hepatocellular adenoma expressing hepatocyte-specific markers." in: Experimental cell research, Vol. 236, Issue 2, pp. 418-26, 1997 (PubMed).

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