Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

BRCA1 Antikörper (C-Term)

BRCA1 Reaktivität: Human IHC (p), IHC (fro) Wirt: Maus Monoclonal GLK-2 unconjugated
Produktnummer ABIN115263
  • Target Alle BRCA1 Antikörper anzeigen
    BRCA1 (Breast Cancer 1 (BRCA1))
    Bindungsspezifität
    • 22
    • 18
    • 15
    • 15
    • 14
    • 11
    • 10
    • 9
    • 8
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1839-1863, C-Term
    Reaktivität
    • 192
    • 36
    • 25
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 162
    • 36
    • 2
    Maus
    Klonalität
    • 166
    • 34
    Monoklonal
    Konjugat
    • 93
    • 18
    • 9
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser BRCA1 Antikörper ist unkonjugiert
    Applikation
    • 127
    • 67
    • 42
    • 42
    • 41
    • 37
    • 28
    • 24
    • 22
    • 12
    • 11
    • 10
    • 9
    • 9
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    BRCA1 recognizes a 22 kDa protein. This antibody stains 94 % of ovarian carcinomas with a mutation in exon 11. However, staining was absent in 100 % of tumors with mutations other than exon 11.
    Cellular Localization: Cytoplasmic.
    Aufreinigung
    None
    Immunogen
    Peptide corresponding to amino acids 1839-1863 of the c-terminus of BRCA1
    Klon
    GLK-2
    Isotyp
    IgM
    Top Product
    Discover our top product BRCA1 Primärantikörper
  • Applikationshinweise
    Immunohistochemistry on frozen and paraffin sections (ABC method: 1/15 - 1/50, Formalinfixed paraffin embedded tissue sections require high temperature antigen unmasking with10 mM citrate buffer, pH 6.0 prior to immunostaining, Incubation period of 30-60 minutesat room temperature). Use ovarian carcinoma as positive control.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Tissue culture supernatant with 0.05 % sodium azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    BRCA1 (Breast Cancer 1 (BRCA1))
    Andere Bezeichnung
    BRCA1 / RNF53 (BRCA1 Produkte)
    Synonyme
    BRCAI antikoerper, BRCC1 antikoerper, BROVCA1 antikoerper, IRIS antikoerper, PNCA4 antikoerper, PPP1R53 antikoerper, PSCP antikoerper, RNF53 antikoerper, iris antikoerper, pscp antikoerper, brcai antikoerper, brcc1 antikoerper, rnf53 antikoerper, brca1 antikoerper, BRCA1 antikoerper, LOC100224649 antikoerper, BRCA1, DNA repair associated antikoerper, breast cancer 1 antikoerper, breast cancer 1, early onset antikoerper, breast cancer 1 L homeolog antikoerper, BRCA1 antikoerper, brca1 antikoerper, LOC755086 antikoerper, Brca1 antikoerper, brca1.L antikoerper
    Hintergrund
    BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full length natures identified.Synonyms: Breast cancer type 1 susceptibility protein, RING finger protein 53
    Gen-ID
    672
    NCBI Accession
    NP_009225
    UniProt
    P38398
    Pathways
    Zellzyklus, DNA Reparatur, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
Sie sind hier:
Kundenservice