Elastin (ELN) Antikörper

Details zu Produkt Nr. ABIN114748, Anbieter: Anmelden zum Anzeigen
Antigen
  • ELN
  • SVAS
  • WBS
  • WS
  • RATTREL11
  • TREL11
  • Trela
  • Trela26
  • AI385707
  • AI480567
  • E030024M20Rik
  • elastin
  • elastin (supravalvular aortic stenosis, Williams-Beuren syndrome)
  • elastin-like
  • ELN
  • Tcur_2481
  • Kfla_2289
  • Eln
  • LOC100620140
Reaktivität
Katze, Hund, Ziege, Meerschweinchen, Human, Schwein, Schaf
69
22
19
14
14
12
4
3
3
3
2
2
1
Wirt
Maus
61
28
2
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
4
3
2
2
Applikation
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
58
42
30
27
15
11
10
10
7
3
2
2
2
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Bovine alpha-Elastin.
Klon BA-4
Isotyp IgG1
Spezifität This antibody recognizes insoluble Elastin, alpha-Elastin, soluble non-cross linked precursor of Elastin (Tropoelastin).
Cellular Localization: Connective tissue.
Reinigung Ascites
Andere Bezeichnung Elastin (ELN Antibody Abstract)
Hintergrund Elastin is an important polymeric protein of connective tissue that imparts elasticity to vertebrate elastic tissues. Elastin is a protein in connective tissue that is elastic and allows many tissues in the body to resume their shape after stretching or contracting. Elastin helps skin to return to its original position when it is poked or pinched. Elastin is also an important load-bearing tissue in the bodies of mammals and used in places where mechanical energy is required to be stored. Elastin is particularly abundant in large elastic blood vessels such as the aorta. It is also very important in the lungs, elastic ligaments, the skin, the bladder, and elastic cartilage. Elastin is composed largely of glycine, proline, and other hydrophobic residues and contains multiple lysine-derived crosslinks, such as desmosines, which link the individual polypeptide chains into a rubberlike network. The hydrophobic regions of the chains, between the crosslinks, are highly mobile. The hydrophobic and crosslinking domains are coded by separate, small (27 to 114 bp) exons that are separated by large introns. The initial translation product is a 72,000-dalton polypeptide, designated tropoelastin. Elastin is made by linking many soluble tropoelastin protein molecules, in a reaction catalyzed by lysyl oxidase, to make a massive insoluble, durable cross-linked array.Synonyms: ELN, Tropoelastin
Gen-ID 280781
NCBI Accession NP_786966
UniProt P04985
Forschungsgebiet Cardiovascular, Extracellular Matrix
Pathways Regulation of Actin Filament Polymerization
Applikationshinweise Immunoprecipitation. Western blotting: 1/100-1/500. Immunohistochemistry on Frozen and Paraffin Embedded Sections: Use 1/50-1/100dilution in an ABC method for 30 minutes at RT. Proteolytic treatment prior toimmunostaining is required for formalin fixed tissue sections. Recommended Positive Control: Heart.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
Western Blotting (WB) image for anti-Elastin (ELN) antibody (ABIN114748) Western blot analysis of human lung cell extract with Elastin antibody ABIN114748
Produkt verwendet in: Schenke-Layland, Madershahian, Riemann, Starcher, Halbhuber, König, Stock: "Impact of cryopreservation on extracellular matrix structures of heart valve leaflets." in: The Annals of thoracic surgery, Vol. 81, Issue 3, pp. 918-26, 2006 (PubMed).

Allgemeine Veröffentlichungen Wrenn, Griffin, Senior, Mecham: "Characterization of biologically active domains on elastin: identification of a monoclonal antibody to a cell recognition site." in: Biochemistry, Vol. 25, Issue 18, pp. 5172-6, 1986 (PubMed).

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