Substance P Antikörper
| Antigen |
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| Synonyme |
NK2, NPK, NKNA, TAC2, Hs.2563, SP, NK1, NK-1, Nkna, PPT-A, MGC151458, 4930528L02Rik |
| Klonalität |
Polyklonal |
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Wirt
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Reaktivität
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Human (39), Ratte (Rattus) (27), Maus (22), Meerschweinchen (17), Rind (Kuh) (16), Kaninchen (16), Pferd (15), Schaf (15), Säugetiere (2), Fisch (1), Affe (1), Schwein (1)
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Applikation
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 Alternativen Immunhistochemie (Gefrierschnitte) (IHC (fro)), Immunfluoreszenz (IF), Immunhistochemie (Paraffinschnitte) (IHC (p))
Immunfluoreszenz (IF) (30), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (20), Durchflusszytometrie (FACS) (19), Immunhistochemie (Paraffinschnitte) (IHC (p)) (16), ELISA (8), Immunhistochemie (IHC) (7), Enzyme Immunoassay (EIA) (4), Western Blot (WB) (4), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), Immunpräzipitation (IP) (2), Immunoelectron Microscopy (IEM) (1), Radioimmunoassay (RIA) (1)
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| Produktnummer |
ABIN114011 |
| Menge |
0.5 ml (5.0 mg/ml) (Varianten) |
| Preis |
300,00 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Produktmerkmale
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Synonyms: Substance-P
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Gen-ID
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6863
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Swiss-Prot
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P20366
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Immunogen
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Synthetic substance P conjugated to Keyhole limpet hemocyanin
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Beschreibung
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Substance P (SP) is currently thought to be one of the most important neurotransmittersand neurotransmitters in the brain. It is an undecapeptide belonging to the tachykininfamily, which consists of excitatory neuropeptides synthesised in neuronal and glial cellsof the human central and peripheral nervous system. Substance P, Neurokinin A,Neuropeptide K, and Neuropeptide gamma are all generated by post-translation cleavageof the precursor Protachykinin-1. Substance P forms the major endogenous ligand forNeurokinin 1 Receptor. The pharmacology of Substance P has been associated with anumber of neurological and psychiatric disorders, namely nociception, migraine, asthma,nausea, inflammatory bowel syndrome, urinary incontinence, anxiety and depression. Ithas also been linked to obesity
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Spezifität
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Stains Substance P secreting cells of the external median eminance of the hypothalamusand specific cells of the GI tract. Stains neuronal structures. Species Reactivity: Tested: Human and Chicken.
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Applikationshinweise
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Immunoflourescence. Immunohistochemistry on Frozen Sections (1/50-1/200). Immunohistochemistry on Paraffin Sections 1/50-1/200). Use of 0.01 M Sodium Citrate buffer, pH 6.0 is recommended. Recommended Positive Control: Appendix. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Konzentration
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5.0 mg/ml
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Buffer
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Phosphate buffered saline, pH 7.2, containing 0.09% Sodium Azide aspreservative.
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Lagerung
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Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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Forschungsgebiet
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Neurologie, Zell-/Gewebemarker
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Publikationen
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Ho, DePalatis: "Substance P immunoreactivity in the median eminence of the North American opossum and domestic fowl." in: Brain research, Vol. 189, Issue 2, pp. 565-9, 1980 (PubMed).
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Alternativen zu Antigen "Substance P", Typ "Antikörper" finden
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Wirte
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Kaninchen (36), Maus (9), Meerschweinchen (4), Ratte (3)
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Reaktivitäten
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Human (39), Ratte (Rattus) (27), Maus (22), Meerschweinchen (17), Rind (Kuh) (16), Kaninchen (16), Pferd (15), Schaf (15), Säugetiere (2), Fisch (1), Affe (1), Schwein (1)
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Applikationen
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Immunfluoreszenz (IF) (30), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (20), Durchflusszytometrie (FACS) (19), Immunhistochemie (Paraffinschnitte) (IHC (p)) (16), ELISA (8), Immunhistochemie (IHC) (7), Enzyme Immunoassay (EIA) (4), Western Blot (WB) (4), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), Immunpräzipitation (IP) (2), Immunoelectron Microscopy (IEM) (1), Radioimmunoassay (RIA) (1)
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Konjugate
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Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
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Epitope
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AA 4-11 (2)
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