Cholinergic Receptor, Muscarinic 1 (CHRM1) Antikörper

Antigen: Cholinergic Receptor, Muscarinic 1 (CHRM1)

Synonyme: M1, HM1, M1R, MGC30125, Chrm-1, mAChR, CHRM1, DKFZp459P0517

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Ratte (Rattus)

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Immunfluoreszenz (IF), Western Blot (WB)

Produktnummer: ABIN113606

Produktbeschreibung

Produktmerkmale: Synonyms: CHRM1, mAChR M1, mAChR-M1

Weitere Bezeichnung: Muscarinic acetylcholine receptor M1

Swiss-Prot: P08482

Immunogen: A peptide analogue of the carboxyl terminal of the Muscarinic M1 receptor covalentlyattached to a carrier protein.

Format: Serum

Beschreibung: The muscarinic cholinergic receptors belong to a larger family of G protein-coupledreceptors. The functional diversity of these receptors is defined by the binding ofacetylcholine and includes cellular responses such as adenylate cyclase inhibition,phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptorsinfluence many effects of acetylcholine in the central and peripheral nervous system. Themuscarinic cholinergic receptor 1 is involved in mediation of vagally-inducedbronchoconstriction and in the acid secretion of the gastrointestinal tract. Muscarinic receptors are so called as they are more sensitive to the effects of the alkaloidmuscarine, rather than nicotine.

Spezifität: Specific for Muscarinic M1 Receptor (carboxyl terminal) (a. a. 451-460). Cross-reactivity: M1 Muscarinic Receptor (451-460) 100%M1 Muscarinic Receptor 60%M2 Muscarinic Receptor (457-466) 0%M2 Muscarinic Receptor 0%M3 Muscarinic Receptor (580-589) 0%M3 Muscarinic Receptor 0%M4 Muscarinic Receptor (469-478) 0%

Anwendungen

Applikationshinweise: ELISAImmunofluoescenceCryo sections: PLP fixed rat brain sections using ABC techniques at a dilution of 1: 5,000. Western immunoblots using whole rat brain homogenerate has been successful at adilution of 1: 800. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Lagerung: Lyophilized: Store at 2-8°C (preferably in a dessicator). Reconstituted: Aliquot and store at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Forschungsgebiet: Neurotransmitter , Hormone, Rezeptoren

Beschränkungen: Nur für Forschungszwecke einsetzbar