ITM2B Antikörper

Produktnummer ABIN113338

Produktdetails anti-ITM2B Antikörper

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Reaktivität: Human

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser ITM2B Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro))

Sequenz: CSRTVKKNII EEN

Spezifität: The antibody recognizes the typical amyloid deposits in brains of patients suffering from the disease. This antibody has been developed against the carboxy terminal extracellular sequence of the mutated BRI protein.

Aufreinigung: Affinity chromatography.

Immunogen: Peptide coupled to carrier protein.

Anwendungsinformationen

Applikationshinweise: Suitable for Immunohistochemistry on frozen sections. Suggested positive control: pathological brain sections. (Not recommended in Western blots).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg /ml

Buffer: PBS, pH 7.2, containing 0.09 % sodium azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2-8 °C (Lyophilized) or reconstituted in small aliquots at -20 °C.

Details zu ITM2B

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Andere Bezeichnung: ITM2B (ITM2B Produkte)

Synonyme: ABRI antikoerper, BRI antikoerper, BRI2 antikoerper, BRICD2B antikoerper, E25B antikoerper, E3-16 antikoerper, FBD antikoerper, imBRI2 antikoerper, AI256040 antikoerper, Bri antikoerper, Bri2 antikoerper, Bricd2b antikoerper, D14Sel6 antikoerper, E25BMM antikoerper, itm2b antikoerper, zgc:55770 antikoerper, zgc:85688 antikoerper, wu:fc05f02 antikoerper, MGC52745 antikoerper, MGC76131 antikoerper, ITM2B antikoerper, itm2bl antikoerper, wu:fb94b03 antikoerper, zgc:64142 antikoerper, integral membrane protein 2B antikoerper, integral membrane protein 2Ba antikoerper, integral membrane protein 2B L homeolog antikoerper, integral membrane protein 2b antikoerper, integral membrane protein 2Bb antikoerper, ITM2B antikoerper, Itm2b antikoerper, itm2ba antikoerper, itm2b.L antikoerper, itm2b antikoerper, itm2bb antikoerper

Hintergrund: The mutated BRI protein (ITM2B) was identified in patients with familial British dementia. The unusual 277 residue precursor protein releases a 34-residue amyloidogenic peptide by the action of the protease furin, leading to the deposition of a protein fragment that seems to be involved in the pathogenesis of familial British dementia.Synonyms: BRI, BRI2, ITM2B, Integral membrane protein 2B, Transmembrane protein BRI

Gen-ID: 9445

NCBI Accession: NP_068839

UniProt: Q9Y287