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Reticulon 1 Antikörper

RTN1 Reaktivität: Human, Maus, Ratte, Hamster WB, IHC (fro), FACS, IHC (p), IF Wirt: Maus Monoclonal MON160 unconjugated
Produktnummer ABIN112383
  • Target Alle Reticulon 1 (RTN1) Antikörper anzeigen
    Reticulon 1 (RTN1)
    Reaktivität
    • 32
    • 30
    • 25
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte, Hamster
    Wirt
    • 39
    • 8
    Maus
    Klonalität
    • 39
    • 8
    Monoklonal
    Konjugat
    • 23
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Reticulon 1 Antikörper ist unkonjugiert
    Applikation
    • 47
    • 17
    • 13
    • 13
    • 11
    • 9
    • 9
    • 7
    • 5
    • 2
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Spezifität
    MON-160 exclusively recognizes the 135 kDa Reticulon-1A protein in immunoblots of NCI-H82 and other SCLC cell lines, and stains normal and pathological neural and neuroendocrine tissues. The epitope of MON-160 is located between amino acid residues 174-337 of Reticulon-1A.
    Aufreinigung
    Purified
    Immunogen
    Partially purified bacterially expressed Reticulon-1A (NSP-A) hybrid protein (beta-GAL-NSP-A 6-776).
    Klon
    MON160
    Isotyp
    IgG1
    Top Product
    Discover our top product RTN1 Primärantikörper
  • Applikationshinweise
    MON-160 is suitable for Immunoblotting, Immunocytochemistry, Immunohistochemistry onfrozen sections and paraffin-embedded tissues and Flow cytometry. Recommended dilutions: 1/50-1/100 for Flow cytometry, and for Immunohistochemistrywith avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and1/50-1/100 for Immunoblotting applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS, 0.09 % Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing/thawing cycles.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store lyophilized antibody at 2-8 °C. After reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -40 °C for longer.
  • Target
    Reticulon 1 (RTN1)
    Andere Bezeichnung
    Reticulon 1 / RTN1 (RTN1 Produkte)
    Synonyme
    NSP antikoerper, 0710005K15Rik antikoerper, 4930441F12Rik antikoerper, Nsp antikoerper, R75279 antikoerper, Rtn1-a antikoerper, Rtn1-b antikoerper, Rtn1-c antikoerper, reticulon-1 antikoerper, RTN1 antikoerper, RTN1-Cw antikoerper, rtn1 antikoerper, XRTN1-A antikoerper, XRTN1-C.1 antikoerper, xrtn1 antikoerper, xrtn1-c antikoerper, RTN1.2 antikoerper, Rtn1-C.2 antikoerper, rtn1-a antikoerper, rtn1b antikoerper, xRTN1 antikoerper, RTN1.1 antikoerper, rtn1a antikoerper, xrtn1-c.1 antikoerper, rtn1l antikoerper, wu:fa21b09 antikoerper, wu:fj35h01 antikoerper, reticulon 1 antikoerper, reticulon-1 antikoerper, reticulon 1 S homeolog antikoerper, reticulon 1 L homeolog antikoerper, reticulon 1b antikoerper, RTN1 antikoerper, Rtn1 antikoerper, rtn1 antikoerper, Rtnl1 antikoerper, LOC100580843 antikoerper, rtn1.S antikoerper, rtn1.L antikoerper, LOC100339591 antikoerper, rtn1b antikoerper
    Hintergrund
    Recently, a novel gene family has been identified and characterized, designated the Reticulons because the proteins encoded by these genes are anchored to the membranes of the endoplasmic reticulum. Reticulon-1 was formerly designated NSP for Neuroendocrine-Specific-Protein, because it is specifically expressed in neural and neuroendocrine tissues. The NSP-gene has been mapped by fluorescence in situ hybridization to human chromosome 14q21-q22. The NSP-gene encodes three overlapping proteins, i.e. Reticulon-1A (NSPA), Reticulon-1B (NSP-B), and Reticulon-1C (NSPC). These proteins were found to be anchored to membranes of the endoplasmic reticulum through their common carboxy-terminal regions. Reticulon-1A is a protein with a molecular weight (MW) of about 135 kDa, which occurs in various isoforms presumably depending on the degree of phosphorylation of serine residues. In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is sofar not found in human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).Synonyms: NSP, Neuroendocrine-specific protein, RTN1, Reticulon-1
    Gen-ID
    6252
    NCBI Accession
    NP_066959
    UniProt
    Q16799
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