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Topoisomerase II alpha Antikörper (N-Term)

TOP2A Reaktivität: Human, Maus, Ratte WB Wirt: Maus Monoclonal AK5 unconjugated
Produktnummer ABIN1109282
  • Target Alle Topoisomerase II alpha (TOP2A) Antikörper anzeigen
    Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))
    Bindungsspezifität
    • 19
    • 18
    • 11
    • 9
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 147
    • 60
    • 29
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    Human, Maus, Ratte
    Wirt
    • 111
    • 37
    Maus
    Klonalität
    • 97
    • 51
    Monoklonal
    Konjugat
    • 73
    • 11
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Topoisomerase II alpha Antikörper ist unkonjugiert
    Applikation
    • 99
    • 56
    • 52
    • 48
    • 26
    • 19
    • 13
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Spezifität
    This antibody reacts with Topo IIa and ß. The antibody detects 170 KD of human Topo IIa and 180 KD of human Topo IIß on Western blot with whole cell lysate.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human (Jurkat, Raji), Mouse (NIH3T3, P19, WR19L), Rat (PC12)
    Aufreinigung
    Protein-A Sepharose
    Immunogen
    Recombinant N-terminal Topoisomerase II fusion protein
    Klon
    AK5
    Isotyp
    IgG1
    Top Product
    Discover our top product TOP2A Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 50 % glycerol, pH 7.2, without preservatives
    Konservierungsmittel
    Without preservative
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store (in aliquots) at -20 °C.
  • Target
    Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))
    Andere Bezeichnung
    TOP2A (TOP2A Produkte)
    Synonyme
    TOP2 antikoerper, TP2A antikoerper, TOP2A antikoerper, Top-2 antikoerper, TOP-2 antikoerper, F12B17.110 antikoerper, F12B17_110 antikoerper, thimet metalloendopeptidase 2 antikoerper, fc08c07 antikoerper, wu:fc08c07 antikoerper, DNA topoisomerase II alpha antikoerper, DNA topoisomerase II, alpha isozyme antikoerper, topoisomerase (DNA) II alpha antikoerper, Zincin-like metalloproteases family protein antikoerper, TOP2A antikoerper, Bm1_08705 antikoerper, Top2a antikoerper, AT5G10540 antikoerper, top2a antikoerper
    Hintergrund
    Eukaryotic DNA Topoisomerase II is a ubiquitous ATP-dependent type II Topoisomerase that play an important role in DNA replication, transcription and recombination by changing the degree of superhelicity, catenation and knotting of topologically closed DNA molecules. Two isoforms of DNA Topoisomerases II have been reported in mammalian cells, Topoisomerase IIa and IIß. cDNA sequence of those isoforms reveals that both type II Topoisomerases are structurally and catalytically close. However, Topoisomerase IIß is expressed with no cell cycle dependence, whereas the expression of Topoisomerase IIa is cell cycle-regulated, peaking in G2-M phase and declining to a minimal level at the end of M phase. Topoisomerase IIa is poly-ubiquitinated and degraded preferentially in the apoptosis-induced human epithermoid carcinoma-derived cell line, MA1, in an ATP-and-ubiquitin-dependent manner. Recent studies also indicated that this isoform is selectively cleaved during Fas-mediated T cell apoptosis and Fas-, Staurosporine- and Anisomycin-mediated Jurkat cell apoptosis.Synonyms: DNA topoisomerase 2-alpha, DNA topoisomerase 2-beta, DNA topoisomerase II alpha isozyme, DNA topoisomerase II beta isozyme, TOP2, Top-2
    Gen-ID
    7153
    NCBI Accession
    NP_001058
    UniProt
    P11388
    Pathways
    Zellzyklus, Mitotic G1-G1/S Phases
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