RAGE Antikörper (Middle Region)

Produktnummer ABIN1108826

Produktdetails anti-RAGE Antikörper

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAGE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Spezifität: This antibody detects RAGE / AGER. No cross reactivity with other proteins.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human, Rat.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide corresponding to a sequence mapping in the middle region of Human advanced glycosylation end-product-specific receptor(RAGE), different from the related Mouse and Rat sequences by two amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 ug/ml.

Buffer: 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium Azide

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu RAGE

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Andere Bezeichnung: RAGE / AGER (AGER Produkte)

Synonyme: RAGE antikoerper, AGER antikoerper, advanced glycosylation end-product specific receptor antikoerper, advanced glycosylation end product-specific receptor antikoerper, MAPK/MAK/MRK overlapping kinase antikoerper, AGER antikoerper, Ager antikoerper, LOC719012 antikoerper

Hintergrund: The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimer's disease. RAGE is also a central cell surface receptor for amphoterin and EN-RAGE. RAGE is associated with sustained NF-kappaB activation in the diabetic microenvironment and has a central role in sensory neuronal dysfunction. Moreover, RAGE propagates cellular dysfunction in several inflammatory disorders and diabetes, and it also functions as an endothelial adhesion receptor promoting leukocyte recruitment.Synonyms: Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products

Gen-ID: 177

NCBI Accession: NP_001127

UniProt: Q15109

Pathways: Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteine