Podocalyxin-Like (PODXL) Antikörper (FITC)

Details zu Produkt Nr. ABIN1108687, Anbieter: Anmelden zum Anzeigen
Antigen
  • PODXL
  • podxl
  • fc18d02
  • wu:fc18d02
  • Gp200
  • PC
  • PCLP
  • PCLP-1
  • AW121214
  • Ly102
  • Pclp1
  • podocalyxin
  • Gp135
  • PCLP1
  • cPCLP1
  • MEP21
  • Podxl
  • podocalyxin like
  • podocalyxin-like
  • uncharacterized LOC100614602
  • PODXL
  • podxl
  • LOC100614602
  • Podxl
Reaktivität
Maus
315
93
82
61
2
2
2
1
1
Wirt
Ratte
190
120
23
20
1
Klonalität (Klon)
Monoklonal ()
Konjugat
FITC
20
19
15
14
12
12
10
9
8
7
7
6
6
5
5
5
4
3
3
3
3
3
2
2
2
1
Applikation
Flow Cytometry (FACS)
215
186
99
96
90
74
56
41
36
10
5
5
3
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen LO cells
Klon 10B9
Isotyp IgG1
Spezifität This antibody reacts with mouse Podocalyxin /PCLP1 (LO).
Reinigung Protein G agarose
Andere Bezeichnung Podocalyxin / PODXL (PODXL Antibody Abstract)
Hintergrund Recent studies with avian embryos and murine embryonic stem cells have suggested that hematopoietic cells are derived from hemangioblasts, the common precursors of hematopoietic and endothelial cells. Hara et al. molecularly cloned podocalyxin-like protein 1 (PCLP1) as a novel surface marker for endothelial-like cells in the AGM (aorta-gonad-mesonephros) region of mouse embryos, where long-term repopulating hematopoietic stem cells (LTR-HSCs) are known to arise. PCLP1+CD45- cells in the AGM region incorporated acetylated low-density lipoprotein and produced both hematopoietic and endothelial cells when cocultured with OP9 stromal cells. Moreover, multiple lineages of hematopoietic cells were generated in vivo when PCLP1+ CD45- cells were injected into neonatal liver of busulfan-treated mice. Anti-Mouse PCLP1 stains LO cells as well as the endothelial-like cells in the AGM culture. LO cell is a novel OSM (oncostatin M)-dependent cell line which exhibits characteristics similar to endothelial-like cells. Today it is reported that the PCLP1 is identical with the Podocalyxin.Synonyms: GCTM-2 antigen, Hematopoietic Stem Cell Marker, PCLP, PCLP-1, PCLP1, Podocalyxin-like protein 1
Gen-ID 27205
NCBI Accession NP_038751
UniProt Q9R0M4
Pathways Tube Formation
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 20 µg/mL
Buffer PBS, 0.09 % NaN3, 1 % BSA
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 2 - 8 °C.
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-Podocalyxin-Like (PODXL) antibody (FITC) (ABIN1108687) anti-Podocalyxin-Like (PODXL) antibody (FITC)
Allgemeine Veröffentlichungen Doyonnas, Nielsen, Chelliah, Drew, Hara, Miyajima, McNagny: "Podocalyxin is a CD34-related marker of murine hematopoietic stem cells and embryonic erythroid cells." in: Blood, Vol. 105, Issue 11, pp. 4170-8, 2005 (PubMed).

Minegishi, Suzuki, Yokomizo, Pan, Fujimoto, Takahashi, Hara, Miyajima, Nishikawa, Yamamoto: "Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos." in: Blood, Vol. 102, Issue 3, pp. 896-905, 2003 (PubMed).

Minehata, Mukouyama, Sekiguchi, Hara, Miyajima: "Macrophage colony stimulating factor modulates the development of hematopoiesis by stimulating the differentiation of endothelial cells in the AGM region." in: Blood, Vol. 99, Issue 7, pp. 2360-8, 2002 (PubMed).

Hara, Nakano, Tanaka, Tamura, Sekiguchi, Minehata, Copeland, Jenkins, Okabe, Kogo, Mukouyama, Miyajima: "Identification of podocalyxin-like protein 1 as a novel cell surface marker for hemangioblasts in the murine aorta-gonad-mesonephros region." in: Immunity, Vol. 11, Issue 5, pp. 567-78, 2000 (PubMed).

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