PMP22 Antikörper (Extracellular Domain, N-Term)

Produktnummer ABIN1108677

Produktdetails anti-PMP22 Antikörper

Target: PMP22 (Peripheral Myelin Protein 22 (PMP22))

Bindungsspezifität: AA 121-133, Extracellular Domain, N-Term

Reaktivität: Human, Rhesusaffen

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PMP22 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequenz: CRHPEWHLNS DYSYG

Spezifität: This antibody recognizes human peripheral myelin protein 22 (PMP22).

Kreuzreaktivität (Details): Species reactivity (tested):Human, rhesus monkey

Aufreinigung: Protein G

Immunogen: Peptide corresponding to amino acids 121-133 in the second extracellular domain of human PMP2 with an extra N-terminal cysteine residue

Klon: CF1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu PMP22

Target: PMP22 (Peripheral Myelin Protein 22 (PMP22))

Andere Bezeichnung: PMP22 (PMP22 Produkte)

Synonyme: CMT1A antikoerper, CMT1E antikoerper, DSS antikoerper, GAS-3 antikoerper, HMSNIA antikoerper, HNPP antikoerper, Sp110 antikoerper, 22kDa antikoerper, Gas-3 antikoerper, Tr antikoerper, trembler antikoerper, pmp22 antikoerper, wu:fa04d03 antikoerper, wu:fa08d03 antikoerper, MGC80653 antikoerper, PMP22 antikoerper, MGC69407 antikoerper, id:ibd2630 antikoerper, wu:fb81f09 antikoerper, zgc:136919 antikoerper, peripheral myelin protein 22 antikoerper, peripheral myelin protein 22a antikoerper, peripheral myelin protein 22 S homeolog antikoerper, peripheral myelin protein 22b antikoerper, PMP22 antikoerper, Pmp22 antikoerper, pmp22a antikoerper, pmp22.S antikoerper, pmp22 antikoerper, pmp22b antikoerper

Hintergrund: PMP22 is a 160 amino acid glycoprotein and contains four hydrophobic domains, presumably transmembrane regions. It is the second most abundant protein in the mammalian nervous system, but is, at least in rodents, also found in other tissues, including the liver and gut. Myelin protein zero (P0) is the most abundant protein in mammalian peripheral nerve myelin. An interaction between P0 and PMP22 has been detected in compact myelin. Defects in PMP22 have been related to Charcot-Marie-Tooth disease (CMT) and inflammatory demyelinating neuropathy (IDP). Immunization with PMP22 induces experimental auto-immune neuritis without central nervous inflammation. Therefore, PMP22 is considered as candidate auto-antigen in inflammatory diseases of the peripheral nervous system, including both acute and chronic inflammatory demyelinating polyradiculoneuropathy.Synonyms: GAS-3, GAS3, Growth arrest-specific protein 3, PMP-22, Peripheral myelin protein 22

Gen-ID: 5376

NCBI Accession: NP_000295

UniProt: Q01453