p53 Antikörper (Tumor Protein P53)

Details for Product anti-TP53 Antibody No. ABIN1108553, Anbieter: Anmelden zum Anzeigen
Antigen
  • tp53
  • p53
  • TP53
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • TpMs
  • BCC7
  • LFS1
  • P53
  • TRP53
  • Trp53
  • Xp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • cellular tumor antigen p53
  • tumor protein p53
  • tumor supressor p53
  • p53 tumor suppressor
  • transformation related protein 53
  • transformation related protein 53, pseudogene
  • trichoplein, keratin filament binding
  • Wistar clone pR53P1 p53 pseudogene
  • CpipJ_CPIJ002758
  • TP53
  • tp53
  • P53
  • Trp53
  • Trp53-ps
  • TCHP
  • Tp53
  • p53-ps
Reaktivität
Human
2428
519
426
188
127
94
87
84
35
23
20
18
17
16
15
14
6
4
4
4
4
3
3
3
2
2
1
1
Wirt
Maus
1372
1169
7
3
1
1
1
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser p53 Antikörper ist unkonjugiert
81
78
65
55
49
48
34
34
26
26
25
25
25
25
25
24
24
24
23
22
22
21
14
14
14
14
14
12
7
5
5
5
5
5
5
5
5
4
3
2
2
2
Applikation
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
1931
772
751
741
651
636
435
347
315
179
72
41
32
31
24
17
17
15
13
9
9
4
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Recombinant Human wild-type p53 protein.
Klon IMD-53
Isotyp IgG2a
Spezifität This antibody reacts to p53 (TP53).
Reinigung Affinity Chromatography
Andere Bezeichnung p53 (TP53) (TP53 Antibody Abstract)
Hintergrund The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to sublethal or severe DNA damage, respectively, by differential transcription of target genes and through transcription-independent apoptotic functions. The p53 protein contains 393 amino acids. Human p53 tumour antigen is Locatedto band 17p13. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.Synonyms: Cellular tumor antigen p53, NY-CO-13, Phosphoprotein p53, Tumor suppressor p53
Gen-ID 7157
NCBI Accession NP_000537
UniProt P04637
Pathways p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Rekonstitution Restore with 1.2 % Sodium Acetate or neutral PBS
Konzentration 0.1 mg/mL
Buffer 1.2 % Sodium Acetate with 2 mg BSA and 0.01 mg Sodium Azide as preservative
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung -20 °C
Informationen zur Lagerung Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Tumor Protein P53 (TP53) antibody (ABIN1108553) anti-Tumor Protein P53 (TP53) antibody
Western Blotting (WB) image for anti-Tumor Protein P53 (TP53) antibody (ABIN1108553) anti-Tumor Protein P53 (TP53) antibody (Image 2)
Allgemeine Veröffentlichungen Casey, Yamanaka, Friess, Kobrin, Lopez, Buchler, Beger, Korc: "p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis." in: Cancer letters, Vol. 69, Issue 3, pp. 151-60, 1993 (PubMed).

Isobe, Emanuel, Givol, Oren, Croce: "Localization of gene for human p53 tumour antigen to band 17p13." in: Nature, Vol. 320, Issue 6057, pp. 84-5, 1986 (PubMed).

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