LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) Antikörper

Details zu Produkt Nr. ABIN1108043, Anbieter: Anmelden zum Anzeigen
Antigen
  • PINCH
  • PINCH-1
  • PINCH1
  • Pinch1
  • RGD1560732
  • LIMS3
  • LIMS3L
  • 2310016J22Rik
  • 4921524A02Rik
  • AI507642
  • AU021743
  • AW551584
  • C430041B13Rik
  • Lims1l
  • LIM and senescent cell antigen-like domains 1
  • LIMS1
  • Lims1
Reaktivität
Human
53
32
32
5
4
4
4
4
4
3
3
2
2
2
Wirt
Maus
43
11
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
38
19
13
13
9
8
6
5
3
1
1
Optionen
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Klon 5G7
Isotyp IgG1
Spezifität This antibody reacts to PINCH.
Kreuzreaktivität (Details) Species reactivity (tested):Human.
Reinigung Ascites
Andere Bezeichnung LIMS1 (LIMS1 Antibody Abstract)
Hintergrund The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.Synonyms: LIM and senescent cell antigen-like-containing domain protein 1, LIMS-1, PINCH, PINCH-1, PINCH1, Particularly interesting new Cys-His protein 1, Renal carcinoma antigen NY-REN-48
Molekulargewicht 37 kDa
Gen-ID 3987
Forschungsgebiet Cancer, Angiogenesis
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) Antikörper (ABIN1108043) anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody
Immunofluorescence (IF) image for anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) Antikörper (ABIN1108043) anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody (Image 2)
Western Blotting (WB) image for anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) Antikörper (ABIN1108043) anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody (Image 3)
Western Blotting (WB) image for anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) Antikörper (ABIN1108043) anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody (Image 4)
ELISA image for anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) Antikörper (ABIN1108043) anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody (Image 5)
Allgemeine Veröffentlichungen Yang, Wang, Hawkins, Chen, Vaynberg, Mao, Tu, Zuo, Wang, Wang, Wu, Tjandra, Qin: "Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase." in: The Journal of biological chemistry, Vol. 284, Issue 9, pp. 5836-44, 2009 (PubMed).

Chiswell, Zhang, Murphy, Boggon, Calderwood: "The structural basis of integrin-linked kinase-PINCH interactions." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 52, pp. 20677-82, 2008 (PubMed).