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HLA-DMA Antikörper

HLA-DMA Reaktivität: Maus WB, IHC (p), IP, FACS, Func, IHC (fro) Wirt: Ratte Monoclonal M5-114 unconjugated
Produktnummer ABIN1107564
  • Target Alle HLA-DMA Antikörper anzeigen
    HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
    Reaktivität
    • 17
    • 3
    • 3
    • 2
    • 1
    Maus
    Wirt
    • 15
    • 2
    • 1
    Ratte
    Klonalität
    • 16
    • 2
    Monoklonal
    Konjugat
    • 13
    • 3
    • 1
    • 1
    Dieser HLA-DMA Antikörper ist unkonjugiert
    Applikation
    • 12
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    The antibody reacts with murine MHC class II glycoproteins. It recognizes a shared determinant on I-Ab, I-Ad, I-Aq, and I-Ed, I-Ek alloantigens, but it does not react with I-Af, I-Ak, I-As. This antibody can inhibit I-A-restricted T cell responses of the H-2b, H-2d, H-2q, H-2u but not H-2f, H-2k, H-2s haplotypes.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Mouse
    Aufreinigung
    Protein-G affinity chromatography
    Reinheit
    > 95 % pure by SDS-PAGE
    Immunogen
    Activated C57BL/6 mouse spleen cells
    Klon
    M5-114
    Isotyp
    IgG2b
    Top Product
    Discover our top product HLA-DMA Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 μm filter sterilized
    Konservierungsmittel
    Azide free
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • Target
    HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
    Abstract
    HLA-DMA Produkte
    Synonyme
    RT1.Ma antikoerper, RT1.DMa antikoerper, HLA-DMA antikoerper, H-2Ma antikoerper, H2-Ma antikoerper, D6S222E antikoerper, DMA antikoerper, HLADM antikoerper, RING6 antikoerper, RT1 class II, locus DMa antikoerper, SLA-DM alpha chain antikoerper, major histocompatibility complex, class II, DM alpha antikoerper, histocompatibility 2, class II, locus DMa antikoerper, RT1-DMa antikoerper, SLA-DMA antikoerper, DLA-DMA antikoerper, H2-DMa antikoerper, HLA-DMA antikoerper
    Hintergrund
    MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells, such as macrophages, dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 amino acid residues long.Synonyms: DM alpha chain, DMA, HLA class II histocompatibility antigen, MHC class II antigen DMA, RING6, Really interesting new gene 6 protein
    Gen-ID
    3108
    NCBI Accession
    NP_006111
    UniProt
    P28067
    Pathways
    Cancer Immune Checkpoints
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