EPH Receptor B4 Antikörper

Produktnummer ABIN1107116

Produktdetails anti-EPH Receptor B4 Antikörper

Target: EPH Receptor B4 (EPHB4)

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser EPH Receptor B4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität (Details): Species reactivity (tested):Mouse

Aufreinigung: Purified

Klon: VEB4-7E4

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu EPH Receptor B4

Target: EPH Receptor B4 (EPHB4)

Andere Bezeichnung: EPHB4 (EPHB4 Produkte)

Synonyme: HTK antikoerper, MYK1 antikoerper, TYRO11 antikoerper, htk antikoerper, myk1 antikoerper, ephB4a antikoerper, tyro11 antikoerper, ephb4b antikoerper, MGC130997 antikoerper, AI042935 antikoerper, Htk antikoerper, MDK2 antikoerper, Myk1 antikoerper, Tyro11 antikoerper, cb646 antikoerper, ephB4 antikoerper, rtk5 antikoerper, EphB-rtk8 antikoerper, cb417 antikoerper, rtk8 antikoerper, EPH receptor B4 antikoerper, EPH receptor B4 L homeolog antikoerper, EPH receptor B4 S homeolog antikoerper, Eph receptor B4 antikoerper, eph receptor B4a antikoerper, eph receptor B4b antikoerper, EPHB4 antikoerper, ephb4.L antikoerper, ephb4.S antikoerper, ephb4 antikoerper, Ephb4 antikoerper, ephb4a antikoerper, ephb4b antikoerper

Hintergrund: Erythropoietin-producing human hepatocellular carcinoma (Eph) receptors and ephrins are membrane proteins. They are classified into 2 broad subclasses, namely A and B, according to structural homologies and binding specificities. Eph receptors are tyrosine kinases, which autophosphorylate upon binding to their cognate ephrin ligands. Eph receptors and ephrins are frequently expressed in reciprocal patterns that correlate with cellular boundaries during embryonic development. The interaction between EphB4 and its ligand, Ephrin-B2, plays an important role in cell-cell, cell-extracellular matrix interactions as well as in cell migration, adhesion and proliferation. During the early stages of vascular development, EphB4 is specifically expressed in venous endothelium, whereas Ephrin-B2 is expressed in arterial endothelium. In mouse embryo's, EphB4 and Ephrin-B2 are essential for embryonic heart development and angiogenesis. In adult microcirculation, EphB4 is not a ubiquitous marker of arterial/venous polarity, but is expressed along both venules and arterioles. Furthermore, EphB4 is upregulated by endothelial cells along blind-ended capillary sprouts versus connecting capillaries. As such, EphB4 is thought to play a role in the patterning of new vessels during angiogenesis. EphB4 is also expressed in a variety of tumor cells, like gastrointestinal, prostate, bladder, breast, liver, lung and ovarian cancers, as well as leukemia, mesothelioma, malignant breast tumors and melanoma. Reduction of EphB4 activity accelerated tumorigenesis in colon and rectum. In head and neck squamous cell carcinoma and endometrial carcinoma, overexpression of EphB4 is inversely related to a poor prognosis. However, in mesothelioma, up-regulation of EphB4 resulted in growth of the tumor. Besides the essential expression of EphB4, coexpression of other EphB4 family members or EphB-ligands may affect tumor cell viability and proliferation as well.Synonyms: Ephrin type-B receptor 4, HTK, TYRO11, Tyrosine-protein kinase TYRO11, Tyrosine-protein kinase receptor HTK

Gen-ID: 13846

NCBI Accession: NP_034274

UniProt: P54761

Pathways: RTK Signalweg