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Endomucin Antikörper

EMCN Reaktivität: Maus WB, IHC (fro), IHC (p), IP Wirt: Ratte Monoclonal V-7C7-1 unconjugated
Produktnummer ABIN1107088
  • Target Alle Endomucin (EMCN) Antikörper anzeigen
    Endomucin (EMCN)
    Reaktivität
    • 44
    • 42
    • 5
    Maus
    Wirt
    • 46
    • 2
    • 2
    • 1
    Ratte
    Klonalität
    • 48
    • 2
    • 1
    Monoklonal
    Konjugat
    • 23
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Endomucin Antikörper ist unkonjugiert
    Applikation
    • 26
    • 26
    • 16
    • 14
    • 8
    • 7
    • 7
    • 5
    • 5
    • 4
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
    Spezifität
    The monoclonal antibody V.7C7.1 recognizes endomucin, type I membrane protein of 248 amino acids (75 kDa) and shows no signicant homology to any known glycoprotein.
    Keine Kreuzreaktivität
    Human
    Kreuzreaktivität (Details)
    Species reactivity (tested):Mouse.
    Aufreinigung
    Purified
    Immunogen
    Mouse endomucin-IgG fusion protein
    Klon
    V-7C7-1
    Isotyp
    IgG2a
    Top Product
    Discover our top product EMCN Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.1 mg/mL
    Buffer
    PBS, 0.02 % Sodium Azide, 0.1 % BSA
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 2-8 °C.
  • Target
    Endomucin (EMCN)
    Andere Bezeichnung
    Endomucin (EMCN Produkte)
    Synonyme
    EMCN2 antikoerper, MUC14 antikoerper, 0610012K22Rik antikoerper, AI315669 antikoerper, Muc14 antikoerper, endomucin antikoerper, EMCN antikoerper, Emcn antikoerper
    Hintergrund
    As a typical mucin-like glycoprotein, endomucin has a high content of serine and threonine residues, suggesting strong O-glycosylation, the sensitivity to O-sialoglycoprotein endopeptidase indicates that endomucin is also a sialomucin. Endomucin is an endothelial-specific sialomucin. It is a constitutively expressed endothelial cell surface protein that is found on all venules but is absent from high endothelial venule cells (HEV) of peripheral and mesenteric lymph nodes as well as Peyer's patches, the specialized site for most efficient lymphocyte trafficking. This could indicate an anti-adhesive function of endomucin, as demonstrated for other sialomucins. Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) is another cell adhesion molecule that contains a mucin-like domain and is expressed on HEV in Peyer's patches, mesenteric lymph nodes and on venules in intestinal lamina propria. In the HEV of mesenteric lymph nodes, the mucin-like domain of a subpopulation of MAdCAM-1 Molecules contains sulfated carbohydrate side chains that interact with L-selectin. The presence of three putative protein kinase C phosphorylation sites in the cytoplasmic tail of endomucin indicates that endomucin has the capacity to be a signaling molecule.Synonyms: EMCN, EMCN2, Endomucin-2, Gastric cancer antigen Ga34, MUC14, Mucin-14
    Gen-ID
    59308
    NCBI Accession
    NP_001156994
    UniProt
    Q9R0H2
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