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CR1L Antikörper (FITC)

CR1L Reaktivität: Ratte WB, IHC (fro), IF, Func, EIA Wirt: Maus Monoclonal TLD-1C11 FITC
Produktnummer ABIN1106830
  • Target Alle CR1L Antikörper anzeigen
    CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))
    Reaktivität
    • 16
    • 12
    • 7
    • 1
    Ratte
    Wirt
    • 27
    • 8
    • 1
    Maus
    Klonalität
    • 27
    • 9
    Monoklonal
    Konjugat
    • 10
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CR1L Antikörper ist konjugiert mit FITC
    Applikation
    • 23
    • 13
    • 13
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Functional Studies (Func), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody reacts with rat-complement regulator Crry.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Rat
    Aufreinigung
    Potein G
    Immunogen
    Rat microglial cells
    Klon
    TLD-1C11
    Isotyp
    IgG1
    Top Product
    Discover our top product CR1L Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.1 mg/mL
    Buffer
    PBS, 0.1 % bovine serum albumin
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C.
  • Target
    CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))
    Andere Bezeichnung
    CR1L / CRRY (CR1L Produkte)
    Synonyme
    CREG antikoerper, Cr1 antikoerper, Crry antikoerper, Mcp antikoerper, mCRY antikoerper, complement C3b/C4b receptor 1 like antikoerper, complement component (3b/4b) receptor 1-like antikoerper, CR1L antikoerper, Cr1l antikoerper
    Hintergrund
    Complement comprises a system of soluble serum proteins that, upon activiation by antibody (classical pathway), sugars (lectin pathway), or bacterial and foreign surfaces (alternative pathway), directly causes cell damage. Complement is constantly activated at low levels in serum, requiring cells to be protect themselves from damage. In human, cells are protected from complement-mediated damage by expression of membrane-bound complement regulatory proteins, which act at serveral points along the cascade. Human cells are protected by decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and membrane attack complex inhibitor protein 1 (MIN1, CD59). Furthermore the rat analogues of DAF, MCP and CD59 have been characterized. Rats and mice express a unique membrane complement regulator of the activating pathways, called complement receptor type-1 related gene Y (Crry). In rats there are two isoforms of Crry, with six or seven short consensus repeats (SCR), encoding 65-70 and 75-85 kDa proteins, respectively, which are both transmembrane anchored. Although Crry has the functional properties of both DAF and MCP, it does not replace them. All rat blood cells express Crry whereas approximately 37 and 39 % of the rat T cells express respectively DAF and CD59. Studies in rat revealed that despite lacking DAF and CD59, these double-negative rat T cells were not more susceptible to homologous complement lysis than cells that expressed both DAF and CD59. However, blocking of the only other known rat complement regulator, Crry, enhanced lysis only at the double-negative cells. In rats, Crry exerts powerful control in the activation pathways where it acts both as a cofactor and as a decay accelerator to inactivate convertases. Crry has been succesfully expressed and refolded in bacteria. The refolded protein has full-complement regulatory activity in vitro, and has been applied in rat models of arthritis and other inflammatory diseases.Synonyms: Antigen 5I2, Complement component receptor 1-like protein, Complement regulatory protein Crry
    Gen-ID
    54243
    NCBI Accession
    NP_001005265
    UniProt
    Q63135
    Pathways
    Komplementsystem
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