Species reactivity (expected):Guinea Pig, Rabbit, Porcine, Bovine, Sheep. Species reactivity (tested):Human.
Aufreinigung
Protein A chromatography
Immunogen
Synthetic peptide corresponding to the amino acids 45-91 of the native molecule conjugated to Bovine Serum Albumin. N-terminal fragment of human MBP (residues 1-118) produced by BNPS-skatole cleavage of pure Human MBP, injected coupled to BSA using carbodiimide.
ELISA. Radioimmunoassays. Immunohistochemistry on Paraffin Sections (10 μg/mL). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
C76307 antikoerper, Hmbpr antikoerper, R75289 antikoerper, golli-mbp antikoerper, mld antikoerper, shi antikoerper, Mbps antikoerper, cb274 antikoerper, fj33b11 antikoerper, mbp antikoerper, wu:fj33b11 antikoerper, wu:fq15b02 antikoerper, zgc:136630 antikoerper, MGC115135 antikoerper, myelin basic protein antikoerper, myelin basic protein a antikoerper, myelin basic protein L homeolog antikoerper, MBP antikoerper, Mbp antikoerper, mbpa antikoerper, mbp antikoerper, mbp.L antikoerper
Hintergrund
The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.Synonyms: MBP, Myelin membrane encephalitogenic protein