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F11R Antikörper (Extracellular Domain) (FITC)

F11R Reaktivität: Human WB, FACS, IF, IHC (fro) Wirt: Maus Monoclonal BV16 FITC
Produktnummer ABIN1106269
  • Target Alle F11R Antikörper anzeigen
    F11R (F11 Receptor (F11R))
    Bindungsspezifität
    • 12
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    Reaktivität
    • 67
    • 45
    • 35
    • 10
    • 7
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 57
    • 15
    • 15
    • 1
    Maus
    Klonalität
    • 49
    • 36
    • 1
    Monoklonal
    Konjugat
    • 47
    • 8
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser F11R Antikörper ist konjugiert mit FITC
    Applikation
    • 61
    • 25
    • 20
    • 17
    • 15
    • 13
    • 9
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    The monoclonal antibody BV16 recognizes the human junction adhesion molecule (JAM)-A.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human
    Aufreinigung
    Potein G
    Immunogen
    Fusion protein consisting of the extracellular domain of human JAM and the Fc portion of human IgGs
    Klon
    BV16
    Isotyp
    IgG1
    Top Product
    Discover our top product F11R Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.1 mg/mL
    Buffer
    PBS, 0.02 % sodium azide, 1 % bovine serum albumin
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or or (in aliquots) at -20 °C for longer.
  • Target
    F11R (F11 Receptor (F11R))
    Andere Bezeichnung
    CD321 / JAM1 (F11R Produkte)
    Synonyme
    CD321 antikoerper, JAM antikoerper, JAM1 antikoerper, JAMA antikoerper, JCAM antikoerper, KAT antikoerper, PAM-1 antikoerper, 9130004G24 antikoerper, AA638916 antikoerper, ESTM33 antikoerper, JAM-1 antikoerper, JAM-A antikoerper, Jcam antikoerper, Jcam1 antikoerper, Ly106 antikoerper, Jam1 antikoerper, F11 receptor antikoerper, F11R antikoerper, F11r antikoerper
    Hintergrund
    Together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3), JAM-A belongs to a family of adhesion proteins with a V-C2 immunoglobulin domain organization and their molecular weight is about 30-40 kDa. JAMs are important for a variety of cellular processes, including tight junction assembly, leukocyte transmigration, platelet activation, angiogenesis and virus binding. JAM-A is expressed by endothelial and epithelial cells, platelets, neutrophils, monocytes, lymphocytes and erythrocytes. Like all other JAMs, JAM-A plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-A also plays an important role in leukocyte transmigration. Leukocyte transmigration can be blocked by antibodies and by soluble JAM-A/Fc fusion proteins. Homophilic JAM-A interactions between leukocytes and the endothelium but also heterophilic interactions of JAM-A with the beta2-integrin leukocyte function-associated antigen-1 (LFA-1) are considered to actively guide leukocytes during transmigration. Several studies imply a role for JAM-A in the initiation of atherosclerosis since JAM-A is upregulated on early atherosclerotic endothelium. The adhesion of activated platelets on the activated endothelium is mediated by homophilic interactions of JAM-A.Synonyms: F11R, JAM-A, JCAM, Junctional adhesion molecule 1, Junctional adhesion molecule A, PAM1, Platelet F11 receptor, Platelet adhesion molecule 1
    Gen-ID
    50848
    NCBI Accession
    NP_058642
    UniProt
    Q9Y624
    Pathways
    Cell-Cell Junction Organization
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