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CD235a/GYPA Antikörper (FITC)

GYPA Reaktivität: Human FACS Wirt: Maus Monoclonal NaM10-6G4 FITC
Produktnummer ABIN1106121
  • Target Alle CD235a/GYPA (GYPA) Antikörper anzeigen
    CD235a/GYPA (GYPA) (Glycophorin A (GYPA))
    Reaktivität
    • 135
    • 17
    • 12
    • 10
    Human
    Wirt
    • 69
    • 68
    • 14
    • 1
    Maus
    Klonalität
    • 94
    • 56
    Monoklonal
    Konjugat
    • 59
    • 14
    • 12
    • 11
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser CD235a/GYPA Antikörper ist konjugiert mit FITC
    Applikation
    • 106
    • 58
    • 43
    • 32
    • 26
    • 24
    • 15
    • 13
    • 13
    • 13
    • 13
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Flow Cytometry (FACS)
    Spezifität
    Clone NAM10-6G4 produces mouse IgG2a immunoglobulins directed against the human CD235a antigen (41 kDa) which is expressed as a cell surface sialoglycoprotein. This antibody may be effectively used for differentiation in acute leukemias, e.g. presence of the GpA antigen on leukemia cells indicates an early erythroid cell lineage of the tumor cells. Using the CD235a antibody, a distinction can be made between erythroleukemia and other (acute) leukemias like e.g. myeloid, lymphoid or undifferentiated leukemias [3,4]. CD235a is often used in combination with detection of H-antigen and/or anti-CD36 antibodies for additional characterization of early erythroid cells. Additional immunophenotyping of early erythroleukemias can be performed by detecting myeloid-associated antigens such as CD13, CD14, CD15, CD33 and CD34, to discriminate from lymphoid lineage-associated antigens like CD2, CD7, CD10 and CD19 [6].
    Aufreinigung
    Affinity chromatography
    Klon
    NaM10-6G4
    Isotyp
    IgG2a
    Top Product
    Discover our top product GYPA Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
  • Target
    CD235a/GYPA (GYPA) (Glycophorin A (GYPA))
    Andere Bezeichnung
    CD235a / GYPA (GYPA Produkte)
    Synonyme
    GYPA antikoerper, gpa antikoerper, AI853584 antikoerper, CD235a antikoerper, GPA antikoerper, GPErik antikoerper, GPSAT antikoerper, HGpMiV antikoerper, HGpMiXI antikoerper, HGpSta(C) antikoerper, MN antikoerper, MNS antikoerper, PAS-2 antikoerper, glycophorin A (MNS blood group) antikoerper, glycophorin A antikoerper, GYPA antikoerper, Gypa antikoerper
    Hintergrund
    Glycophorin A (GpA) antigen (CD235a) is exclusively expressed on human erythroid cells and their progenitors and not on lymphoid or granulocytic progenitor cells and therefore is a very useful marker for detection of the erythroid cell lineage [1,2]. CD235a seems to be absent from erythroid colony forming cells in bone marrow, but is present during maturation from (pro-)erythroid blast cells to mature erythrocytes. CD235a is clinically important in the classification of leukemias.Synonyms: GPA, Glycophorin-A, MN sialoglycoprotein, PAS-2, Sialoglycoprotein alpha
    Gen-ID
    2993
    NCBI Accession
    NP_002090
    UniProt
    P02724
    Pathways
    Maintenance of Protein Location
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