Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

CD130/gp130 Antikörper

IL6ST Reaktivität: Human WB, FACS, IP, Func Wirt: Maus Monoclonal B-P4 unconjugated
Produktnummer ABIN1105847
  • Target Alle CD130/gp130 (IL6ST) Antikörper anzeigen
    CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
    Reaktivität
    • 140
    • 66
    • 56
    • 20
    • 18
    • 18
    • 17
    • 4
    • 1
    • 1
    Human
    Wirt
    • 115
    • 27
    • 4
    • 2
    • 1
    Maus
    Klonalität
    • 117
    • 32
    Monoklonal
    Konjugat
    • 53
    • 15
    • 9
    • 9
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD130/gp130 Antikörper ist unkonjugiert
    Applikation
    • 99
    • 39
    • 39
    • 31
    • 29
    • 26
    • 18
    • 13
    • 10
    • 9
    • 9
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)
    Spezifität
    Recognizes the soluble antigen. Recognizes the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human.
    Aufreinigung
    Ion Exchange Chromatography
    Sterilität
    0.22 μm filtered
    Immunogen
    Natural soluble gp130. Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells.
    Klon
    B-P4
    Isotyp
    IgG1
    Top Product
    Discover our top product IL6ST Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Phosphate-buffered saline without Carrier and preservatives. This prodcut is sterile-filtered through 0.22 μm and treated to remove Endotoxins.
    Konservierungsmittel
    Without preservative
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
    Andere Bezeichnung
    CD130 / IL6ST (IL6ST Produkte)
    Synonyme
    CD130 antikoerper, CDW130 antikoerper, GP130 antikoerper, IL-6RB antikoerper, 5133400A03Rik antikoerper, AA389424 antikoerper, BB405851 antikoerper, D13Ertd699e antikoerper, gp130 antikoerper, Ac1055 antikoerper, Gp130 antikoerper, Il-6rb antikoerper, IL-6 antikoerper, interleukin 6 signal transducer antikoerper, IL6ST antikoerper, Il6st antikoerper, il6st antikoerper
    Hintergrund
    IL-6 activates intracellular signaling through binding a receptor consisting of an 80 kDa ligand-binding protein (IL-6R) and a second protein of 130 kDa. IL-6 first binds to IL-6R which subsequently associates with a gp130 dimer. The active signaling complex consists of at minimum IL-6, IL-6R and a dimer of two gp130 proteins that are linked by a disulfide bond. A soluble form of IL-6R is generated by proteolytic cleavage of the membrane-bound precursor and can function as an agonistic molecule that can actively participate in cell-tocell signaling. The second subunit of the IL-6 complex, gp130, also functions as a component of several additional receptor complexes including leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11. LIF binds to the LIF receptor with low affinity and to a complex of the LIF receptor and gp130 with high affinity, while OSM appears to bind to gp130 with low affinity and to a complex of gp130 and the LIF receptor with high affinity.Synonyms: IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta
    Gen-ID
    3572
    NCBI Accession
    NP_002175
    UniProt
    P40189
    Pathways
    JAK-STAT Signalweg, Cellular Glucan Metabolic Process, Autophagie, Smooth Muscle Cell Migration, Cancer Immune Checkpoints
Sie sind hier:
Kundenservice