PVRL2 Antikörper (Extracellular Domain) (FITC)

Produktnummer ABIN1105754

Produktdetails anti-PVRL2 Antikörper (FITC)

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Bindungsspezifität: Extracellular Domain

Reaktivität: Human, Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser PVRL2 Antikörper ist konjugiert mit FITC

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Protein G

Immunogen: Extracellular domain of mouse nectin-2

Klon: 502-57

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu PVRL2

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Andere Bezeichnung: CD112 / Nectin 2 (PVRL2 Produkte)

Synonyme: prr2 antikoerper, AI325026 antikoerper, AI987993 antikoerper, Cd112 antikoerper, MPH antikoerper, Pvr antikoerper, Pvs antikoerper, nectin-2 antikoerper, CD112 antikoerper, HVEB antikoerper, PRR2 antikoerper, PVRR2 antikoerper, nectin cell adhesion molecule 2 antikoerper, Nectin2 antikoerper, NECTIN2 antikoerper

Hintergrund: Nectin (originally isolated as poliovirus receptor-related protein (PRR)) is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectin is colocalized with afadin at cadherin-based cell-cell adherence junctions in various tissues and cell lines. The nectin family consist of nectin-1, nectin-2 and nectin-3. Nectin-2 also known as PRR2 or CD112 is a plasma membrane adhesion molecule localized at adherens junctions which is widely expressed in various cell lines including neuronal, endothelial, epithelial and hematopoietic cells. Next to its role in adherens junctions it functions as alphaherpus virus receptor and acts also as intercellular adhesion molecule and pseudorabies virus receptor. Disruption of mouse nectin-2 leads to infertility of male mice.Synonyms: HVEB, Herpes virus entry mediator B, Nectin-2, PRR2, PVRL2, Poliovirus receptor-related protein 2

UniProt: P32507

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization