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Caspase 2 Antikörper (C-Term)

CASP2 Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1105674
  • Target Alle Caspase 2 (CASP2) Antikörper anzeigen
    Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))
    Bindungsspezifität
    • 15
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 100
    • 38
    • 25
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 91
    • 7
    • 4
    Kaninchen
    Klonalität
    • 80
    • 22
    Polyklonal
    Konjugat
    • 60
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Caspase 2 Antikörper ist unkonjugiert
    Applikation
    • 74
    • 34
    • 23
    • 14
    • 14
    • 14
    • 10
    • 8
    • 8
    • 6
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    This antibody detects Caspase-2 (C-term). No cross reactivity with other proteins.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Mouse.
    Species reactivity (tested):Human, Rat.
    Aufreinigung
    Immunoaffinity Chromatography
    Immunogen
    Synthetic peptide mapping at the C-terminal of Human Caspase 2 .Remarks: Sequence is identical to the related Rat and Mouse sequence.
    Isotyp
    IgG
    Top Product
    Discover our top product CASP2 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Buffer
    0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium Azide, 5 mg BSA
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))
    Andere Bezeichnung
    Caspase-2 (CASP2 Produkte)
    Synonyme
    xCaspase-2 antikoerper, Caspase-2 antikoerper, ICH-1 antikoerper, Nedd2 antikoerper, CASP-2 antikoerper, ICH1 antikoerper, NEDD-2 antikoerper, NEDD2 antikoerper, PPP1R57 antikoerper, ICH-1L/1S antikoerper, ICH1L1S antikoerper, caspase 2 antikoerper, caspase 2 L homeolog antikoerper, caspase-2 antikoerper, CASP2 antikoerper, casp2.L antikoerper, CpipJ_CPIJ008254 antikoerper, Casp2 antikoerper
    Hintergrund
    Caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Caspase-2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.Synonyms: CASP-2, CASP2, ICH-1 protease, ICH1, NEDD2, Neural precursor cell expressed developmentally down-regulated protein 2
    Gen-ID
    835
    NCBI Accession
    NP_116764
    UniProt
    P42575
    Pathways
    Apoptose, Caspase Kaskade in der Apoptose, Neurotrophin Signalübertragung
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