C1S Antikörper

Produktnummer ABIN1105612

Produktdetails anti-C1S Antikörper

Target: C1S (Complement Component 1, S Subcomponent (C1S))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C1S Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Functional Studies (Func)

Spezifität: Monoclonal antibody M81 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). The epitope recognised by the antibody M81 is domain IV and/or V of the gamma-domain of activated C1s. It blocks C4 activation and C4 binding to activated C1s. The antibody reacts around the binding site of C1s and reacts with both active and inactive C1s.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein G

Klon: M81

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu C1S

Target: C1S (Complement Component 1, S Subcomponent (C1S))

Andere Bezeichnung: C1s (C1S Produkte)

Synonyme: AA959438 antikoerper, AI255193 antikoerper, AI327365 antikoerper, C1sa antikoerper, r-gsp antikoerper, C1S antikoerper, complement C1s antikoerper, complement component 1, s subcomponent 1 antikoerper, complement component 1, s subcomponent antikoerper, complement component 1, s subcomponent L homeolog antikoerper, complement C1s subcomponent antikoerper, C1S antikoerper, C1s1 antikoerper, C1s antikoerper, c1s antikoerper, c1s.L antikoerper, LOC100558615 antikoerper

Hintergrund: Activated C1s is a glycosylated single-polypeptide zymogen, MW 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a.Synonyms: C1 esterase, Complement 1s, Complement C1s, Complement C1s subcomponent, Complement component 1 subcomponent s

Gen-ID: 716

NCBI Accession: NP_001725

UniProt: P09871

Pathways: Komplementsystem