Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) Antikörper

Antigen: Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2)

Synonyme: HSD11B2, AME, AME1, HSD2, HSD11K, SDR9C3, MGC127544, MGC81883, 11-HSD2

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus

Applikation: Western Blot (WB), Immunzytochemie (ICC)

Produktnummer: ABIN110240

Produktbeschreibung

Weitere Bezeichnung: 11beta-Hydroxysteroid Dehydrogenase (Type 2)

Immunogen: human 11beta-Hydroxysteroid dehydrogenase (Type 2) (11beta-HSD2) amino acids

Beschreibung: 11beta-HSD2 plays a critical role in normal physiology in the corticosteroid regulation of sodium homeostasis and the pathophysiology of hypertension by converting active cortisol to inactive cortisone. Mutation in the gene encoding 11beta-HSD2 results in cortisol induction of hypertension and hypokalemia, a syndrome of apparent mineralocorticoid excess. 11beta-HSD2 mRNA and protein are expressed in placenta and mineralocorticoid target tissues, particularly the kidney. In mouse, expression of this enzyme is tissue-specific and developmentally regulated, indicating the importance of the enzyme in controlling glucocorticoid-mediated maturation. Cayman's 11beta-HSD2 polyclonal antibody can be used for western blotting and immunochemical analysis of 11beta-HSD2 from samples of human, rat, and mouse. The antibody detects a band at 44 kDa in tissues such as kidney and cell lines including Caco-2 cells and HT-29 cells.

Spezifität: Human 11beta-HSD2: +, murine 11beta-HSD2: +, rat 11beta-HSD2: +

Anwendungen

Buffer: Affinity-purified IgG

Lagerung: 1 year

Forschungsgebiet: Enzyme

Beschränkungen: Nur für Forschungszwecke einsetzbar