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Ankyrin G Antikörper (C-Term)

ANK3 Reaktivität: Human WB, IF/ICC Wirt: Maus Monoclonal S106-20 unconjugated
Produktnummer ABIN1098195
  • Target Alle Ankyrin G (ANK3) Antikörper anzeigen
    Ankyrin G (ANK3) (Ankyrin 3, Node of Ranvier (Ankyrin G) (ANK3))
    Bindungsspezifität
    • 12
    • 5
    • 1
    C-Term
    Reaktivität
    • 27
    • 3
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 16
    • 13
    • 1
    Maus
    Klonalität
    • 16
    • 14
    Monoklonal
    Konjugat
    • 10
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Ankyrin G Antikörper ist unkonjugiert
    Applikation
    • 15
    • 14
    • 11
    • 7
    • 6
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (fixed cells) (IF/ICC)
    Verwendungszweck
    Anti-Ankyrin-G Mouse Monoclonal Antibody
    Spezifität
    This antibody recognizes human, mouse, and rat Ankyrin-G.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein G affinity chromatography.
    Immunogen
    Fusion protein corresponding to ~1,000 C-terminal amino acids of human Ankyrin G (accession no. NP_066267.2).
    Klon
    S106-20
    Isotyp
    IgG1
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  • Applikationshinweise
    Immunoblotting: use at 1-2 μg/mL. A band of >200 kDa is detected.
    These are recommended concentrations.
    Enduser should determine optimal concentrations for their applications.
    Positive control: rat brain membranes.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Rekonstitution
    Dilute in PBS or medium that is identical to that used in the assay system.
    Konzentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    This product is stable for at least 1 year at -20°C. Freeze in multiple aliquots to avoid repeated freeze-thaw cycles.
  • Target
    Ankyrin G (ANK3) (Ankyrin 3, Node of Ranvier (Ankyrin G) (ANK3))
    Andere Bezeichnung
    Ankyrin-G (ANK3 Produkte)
    Synonyme
    ANK3 antikoerper, ankyrin-G antikoerper, 2900054D09Rik antikoerper, AI314020 antikoerper, Ank-3 antikoerper, AnkG antikoerper, Ankyrin-3 antikoerper, Ankyrin-G antikoerper, ANKYRIN-G antikoerper, ankyrin 3 antikoerper, ankyrin 3, node of Ranvier (ankyrin G) antikoerper, ankyrin 3, epithelial antikoerper, ANK3 antikoerper, legA6 antikoerper, PB000272.02.0 antikoerper, PY00018 antikoerper, ank3 antikoerper, Ank3 antikoerper
    Hintergrund
    Ankyrin-3,In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). {PubMed:17974005}., [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {PubMed:17974005}.,Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton. Ankyrins have binding sites for the beta subunit of spectrin and for at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers, and ion transporters in the plasma membrane.,Cytoplasm, cytoskeleton, Cell projection, axon, Cell membrane, sarcolemma, Cell junction, synapse, postsynaptic cell membrane, Lysosome, Cell membrane, sarcolemma, T-tubule,ANK-3, Ankyrin-G
    UniProt
    Q12955
    Pathways
    Synaptic Membrane, Maintenance of Protein Location, Skeletal Muscle Fiber Development
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