HAS2 Antikörper (AA 67-170)

Produktnummer ABIN1098124

Produktdetails anti-HAS2 Antikörper

Target: HAS2 (Hyaluronan Synthase 2 (HAS2))

Bindungsspezifität: AA 67-170

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HAS2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human HAS2 (AA: 67-170) expressed in E. coli.

Klon: 4-00E-07

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:100 - 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-HAS2 Antikörper (ABIN1098124)

Okuda, Kobayashi, Xia, Watabe, Pai, Hirota, Xing, Liu, Pandey, Fukuda, Modur, Ghosh, Wilber, Watabe: "Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells." in: Cancer research, Vol. 72, Issue 2, pp. 537-47, (2012) (PubMed).

Jokela, Makkonen, Oikari, Kärnä, Koli, Hart, Tammi, Carlberg, Tammi: "Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1." in: The Journal of biological chemistry, Vol. 286, Issue 38, pp. 33632-40, (2011) (PubMed).

Details zu HAS2

Target: HAS2 (Hyaluronan Synthase 2 (HAS2))

Andere Bezeichnung: HAS2 (HAS2 Produkte)

Synonyme: DG42 antikoerper, XHas2 antikoerper, Has2 antikoerper, hyaluronan synthase 2 antikoerper, hyaluronan synthase 2 S homeolog antikoerper, has2 antikoerper, HAS2 antikoerper, Has2 antikoerper, SHAS2 antikoerper, has2.S antikoerper

Hintergrund: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

Molekulargewicht: 63.5 kDa

Gen-ID: 3037

HGNC: 3037

Pathways: Glycosaminoglycan Metabolic Process