TIMP Metallopeptidase Inhibitor 4 (TIMP4) Antikörper

Antigen: TIMP Metallopeptidase Inhibitor 4 (TIMP4)

Synonyme: TIMP-4, TIMP4

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Kaninchen, Pavian

Applikation: Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN107625

Produktbeschreibung

Weitere Bezeichnung: Tissue Inhibitor of Metalloproteinase-4 (TIMP-4)

Immunogen: A synthetic peptide derived from the C-terminus region of the human TIMP-4.

Format: Ig-fraction, Purified

Spezifität: This antibody reacts with a 23kD protein, known as TIMP-4. TIMPs form tight inhibitory complexes with MMPs, which are involved, in matrix degradation and in tumor invasiveness and metastasis. TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

Anwendungen

Applikationshinweise: Titer/Working Dilution: This antibody may be diluted to a titer of 1:25-1:50 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Positive Control: Breast carcinoma. Cellular localization: Cytoplasmic Other Applications: immunoprecipitation, and Western blottin (!:100-500).

Konzentration: 100ug/ml approximately

Buffer: Purified immunoglobulin fraction of rabbit antiserum against human TIMP-4 containing sodium azide as preservative.

Lagerung: Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.

Forschungsgebiet: Krebs, Extrazelluläre Matrix, Inflammation

Beschränkungen: Für Forschungszwecke. Als CE-zertifizierter Antikörper in der Europäischen Union für In Vitro Diagnostik (IVD) zugelassen.

Publikationen

Publikationen: Liu, Wang, Greene et al.: "Preparation and characterization of recombinant tissue inhibitor of metalloproteinase 4 (TIMP-4)." in: The Journal of biological chemistry, Vol. 272, Issue 33, pp. 20479-83, 1997 (PubMed).