Microtubule-Associated Protein tau (MAPT) Antikörper

Antigen: Microtubule-Associated Protein tau (MAPT)

Synonyme: TAU, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, FLJ31424, MGC138549, Tau, Mtapt, AI413597, AW045860, pTau, RNPTAU, MGC156663, tau, MGC134287, xtp, MAPT

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN107252

Produktbeschreibung

Weitere Bezeichnung: Tau

Immunogen: Recombinant protein encoding C-terminal part of human tau.

Format: Ig-fraction, Purified

Spezifität: This antibody reacts with a 45 68 kD protein. The brain tissue of Alzheimers disease is characterized by an abundance of neurofibrillary tangles, neuropil threads and abnormal neuritis in senile plaques. Tau protein are microtubule-associate protein (MAPs), present in the tangles. This antibody stains neurofibrillary tangles, neuropil threads and neuritic plaques. It also stains astrocytes and ribosomes.

Anwendungen

Applikationshinweise: Titer/Working Dilution: This antibody may be diluted to a titer of 1:50-1:100 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Staining Protocol: We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation conditions should be determined by the user. Suitable for formalin fixed paraffin tissue sections. No special pretreatment is required. Positive Control: Alzheimers disease brain. Cellular localization: Cytoplasmic

Konzentration: 100ug/ml approximately

Buffer: Purified immunoglobulin fraction of rabbit antiserum against Tau containing sodium azide as preservative.

Lagerung: Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.

Forschungsgebiet: Zytoskelett

Beschränkungen: Für Forschungszwecke. Als CE-zertifizierter Antikörper in der Europäischen Union für In Vitro Diagnostik (IVD) zugelassen.

Bilder

Formalin fixed paraffin embedded human Alzheimer brain stained with tau antibody

Publikationen

Publikationen: Butner, Kirschner: "Tau protein binds to microtubules through a flexible array of distributed weak sites." in: The Journal of cell biology, Vol. 115, Issue 3, pp. 717-30, 1991 (PubMed).