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ING4 Antikörper (Isoform 1)

ING4 Reaktivität: Human WB, ELISA Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN105223
  • Target Alle ING4 Antikörper anzeigen
    ING4 (Inhibitor of Growth Family, Member 4 (ING4))
    Bindungsspezifität
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 164-175, Isoform 1
    Reaktivität
    • 29
    • 16
    • 13
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 26
    • 3
    Ziege
    Klonalität
    • 28
    • 1
    Polyklonal
    Konjugat
    • 18
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ING4 Antikörper ist unkonjugiert
    Applikation
    • 17
    • 12
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This affinity purified antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding aa 164-175 of Human p29 ING4 protein (Inhibitor of growth family, member 4). This sequence only shows homology to for ING4.
    Isotyp
    IgG
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  • Applikationshinweise
    This affinity-purified antibody has been tested for use in ELISA against the immunizing peptide.  Specific conditions for western blotting reactivity should be optimized by the end user.  Expect a band at approximately 29 kDa in size corresponding to ING4 isoform 1 by western blotting in the appropriate cell lysate or extract.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.28 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Colla, Tagliaferri, Morandi, Lunghi, Donofrio, Martorana, Mancini, Lazzaretti, Mazzera, Ravanetti, Bonomini, Ferrari, Miranda, Ladetto, Neri, Neri, Greco, Mangoni, Bonati, Rizzoli, Giuliani et al.: "The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha ..." in: Blood, Vol. 110, Issue 13, pp. 4464-75, (2007) (PubMed).

    Unoki, Shen, Zheng, Harris: "Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility." in: The Journal of biological chemistry, Vol. 281, Issue 45, pp. 34677-86, (2006) (PubMed).

  • Target
    ING4 (Inhibitor of Growth Family, Member 4 (ING4))
    Andere Bezeichnung
    p29 ING4 (ING4 Produkte)
    Synonyme
    wu:fb11d09 antikoerper, wu:fb50e02 antikoerper, zgc:110619 antikoerper, ING4 antikoerper, my036 antikoerper, p29ING4 antikoerper, D6Wsu147e antikoerper, D6Xrf92 antikoerper, inhibitor of growth family, member 4 antikoerper, inhibitor of growth family member 4 antikoerper, ing4 antikoerper, ING4 antikoerper, Ing4 antikoerper
    Hintergrund
    P29 ING4 is a tumor suppressor protein similar to ING1 that  may inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. p29 ING4 has been shown to suppress brain tumor angio-genesis through transcriptional repression of RelA/ NFKB3 target genes when complexed with RelA.  p29 ING4 may also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. p29 ING4 shows a nuclear localization and interacts with EP300, TP53, RelA, inhibits cell growth, and induces apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. Multiple alternatively spliced transcript variants have been observed.  The accession number listed below is for variant (1) that encodes the longest isoform.
    Synonyms: NG-4 antibody, ING1 like protein antibody, Inhibitor of growth family member 4 antibody, Inhibitor of growth family member 4 long isoform antibody, Inhibitor of growth protein 4 antibody, MGC12557 antibody
    Gen-ID
    51147
    UniProt
    Q9UNL4
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