Myeloid Cell Leukemia (Mcl-1) Antikörper

Antigen: Myeloid Cell Leukemia (Mcl-1)

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN104437

Produktbeschreibung

Immunogen: A synthetic peptide corresponding to aa 121-139 of human MCl-1.

Format: Ig-fraction, Purified

Spezifität: This antibody reacts with a 42 kD protein. Myeloid cell leukemia-1 (MCL-1) is a member of the bcl-2 family. The carboxy terminal of Mcl-1 and bcl-2 share significant sequence homology. Expression of Mcl-1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents, along with increases in GADD45 and Bax and a decrease in bcl-2.

Anwendungen

Applikationshinweise: Titer/Working Dilution: This antibody may be diluted to a titer of 1:25-1:50 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Positive Control: Tonsil. Cellular localization: Cytoplasmic, nuclear Other Applications: Immunoprecipitation, Western blotting (1:100-500).

Konzentration: 100ug/ml approximately

Buffer: Purified immunoglobulin fraction of rabbit antiserum against MCL-1 containing sodium azide as preservative.

Lagerung: Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.

Forschungsgebiet: Krebs

Beschränkungen: Für Forschungszwecke. Als CE-zertifizierter Antikörper in der Europäischen Union für In Vitro Diagnostik (IVD) zugelassen.

Bilder

Formalin fixed paraffin embedded human tonsil stained with Mcl-1 antibody