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IDO1 Antikörper

IDO1 Reaktivität: Human, Maus WB, ELISA, IHC, FACS, IP Wirt: Maus Monoclonal 10-1 unconjugated
Produktnummer ABIN1043734
  • Target Alle IDO1 Antikörper anzeigen
    IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
    Reaktivität
    • 62
    • 31
    • 16
    • 8
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 57
    • 11
    • 1
    • 1
    Maus
    Klonalität
    • 56
    • 15
    Monoklonal
    Konjugat
    • 48
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IDO1 Antikörper ist unkonjugiert
    Applikation
    • 63
    • 32
    • 23
    • 19
    • 16
    • 15
    • 14
    • 8
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunoprecipitation (IP)
    Spezifität
    Anti-IDO1 was purified from concentrated tissue culture supernate by Protein G chromatography followed by extensive dialysis against the buffer stated above. This antibody is specific for human and mouse IDO1 protein. A BLAST analysis was used to suggest cross-reactivity with IDO1 from human and mouse sources based on 100% homology with the immunizing sequence. Cross-reactivity with IDO1 from other sources has not been determined.
    Produktmerkmale
    Indoleamine 2, 3-dioxygenase1 (IDO1) is a 41-42 kD intracellular enzyme that catabolizes tryptophan into kynurenine. IDO1 modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO1 effects on immune suppression are due to decreased tryptophan availability and the generation of tryptophan metabolites, resulting in negative effects on T lymphocytes, including proliferation, function and survival. IDO1 may be involved in the suppression of the immune response to tumors, and blocking the IDO1 pathway may be a potential target for immuno and cancer therapy. IDO1 is expressed in a wide variety of tissues and can be upregulated by interferon gamma and other inflammatory cytokines.
    Sterilität
    Sterile filtered
    Immunogen
    Anti-IDO1 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with fragment of recombinant human and mouse IDO1 protein followed by hybridoma development.
    Immunogen Type: RecombinantProtein
    Klon
    10-1
    Isotyp
    IgG3
    Top Product
    Discover our top product IDO1 Primärantikörper
  • Applikationshinweise
    Anti-IDO1 antibody has been tested for use in ELISA, Western Blot, IP, IHC, and Flow Cytometry. Specific conditions for reactivity should be optimized by the end user.
    Kommentare

    Gene Name: Ido1

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
    Haltbarkeit
    12 months
  • Meyer, Klatte, Dinh, Harries, Reithmayer, Meyer, Sinclair, Paus: "Evidence that the bulge region is a site of relative immune privilege in human hair follicles." in: The British journal of dermatology, Vol. 159, Issue 5, pp. 1077-85, (2009) (PubMed).

    Batista, Juhász, Muzik, Kupsky, Barger, Chugani, Mittal, Sood, Chakraborty, Chugani: "Imaging correlates of differential expression of indoleamine 2,3-dioxygenase in human brain tumors." in: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, Vol. 11, Issue 6, pp. 460-6, (2009) (PubMed).

    Zhu, Ji, Wang, Zhang, Liu, Zhang, Matsushima, Cao, Zhang: "Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 11, pp. 8226-33, (2007) (PubMed).

    Mellor, Munn: "IDO expression by dendritic cells: tolerance and tryptophan catabolism." in: Nature reviews. Immunology, Vol. 4, Issue 10, pp. 762-74, (2004) (PubMed).

  • Target
    IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
    Andere Bezeichnung
    IDO1 (IDO1 Produkte)
    Synonyme
    INDO antikoerper, ido antikoerper, indo antikoerper, IDO antikoerper, cd107b antikoerper, IDO1 antikoerper, IDO-1 antikoerper, Ido antikoerper, Indo antikoerper, indoleamine 2,3-dioxygenase 1 antikoerper, indoleamine 2,3-dioxygenase 1 L homeolog antikoerper, indoleamine 2,3-dioxygenase 1-like antikoerper, IDO1 antikoerper, ido1.L antikoerper, ido1 antikoerper, Ido1 antikoerper, LOC100050681 antikoerper
    Hintergrund
    Indoleamine 2, 3-dioxygenase1 (IDO1) is a 41-42 kD intracellular enzyme that catabolizes tryptophan into kynurenine. IDO1 modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO1 effects on immune suppression are due to decreased tryptophan availability and the generation of tryptophan metabolites, resulting in negative effects on T lymphocytes, including proliferation, function and survival. IDO1 may be involved in the suppression of the immune response to tumors, and blocking the IDO1 pathway may be a potential target for immuno and cancer therapy. IDO1 is expressed in a wide variety of tissues and can be upregulated by interferon gamma and other inflammatory cytokines.
    Synonyms: Ido, Indo, Indoleamine 2,3-dioxygenase 1, Indoleamine-pyrrole 2,3-dioxygenase, Ido1, Ido-1
    Gen-ID
    3620
    NCBI Accession
    NP_002155
    UniProt
    P14902
    Pathways
    Activated T Cell Proliferation
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