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PDCD4 Antikörper (pSer457)

PDCD4 Reaktivität: Human, Maus, Ratte, Xenopus laevis WB, ELISA, IHC Wirt: Maus Monoclonal 2E10-C12 unconjugated
Produktnummer ABIN1043728
  • Target Alle PDCD4 Antikörper anzeigen
    PDCD4 (Programmed Cell Death 4 (PDCD4))
    Bindungsspezifität
    • 15
    • 15
    • 13
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer457
    Reaktivität
    • 104
    • 70
    • 60
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Human, Maus, Ratte, Xenopus laevis
    Wirt
    • 96
    • 6
    • 2
    • 1
    Maus
    Klonalität
    • 92
    • 13
    Monoklonal
    Konjugat
    • 59
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PDCD4 Antikörper ist unkonjugiert
    Applikation
    • 76
    • 44
    • 36
    • 16
    • 14
    • 14
    • 13
    • 9
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Spezifität
    Pdcd4 phospho S457 Antibody was purified from concentrated tissue culture supernate by Protein A chromatography. This antibody is specific for human Pdcd4 protein phosphorylated at Ser457.  A BLAST analysis was used to suggest cross-reactivity with Pdcd4 from human, mouse, rat and Xenopus based on 100% homology with the immunizing sequence.  Cross-reactivity with Pdcd4 from other sources has not been determined.
    Produktmerkmale
    Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphoryl-ation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun. Ideal for researchers involved in Cell Signaling, Cancer and Signal Transduction research.
    Sterilität
    Sterile filtered
    Immunogen
    Anti-Pdcd4 phospho S457 Antibody was produced by repeated immunizations with a synthetic peptide corresponding to residues surrounding Ser457 of the human Pdcd4 protein.
    Immunogen Type: Peptide
    Klon
    2E10-C12
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product PDCD4 Primärantikörper
  • Applikationshinweise
    This monoclonal antibody is suitable for ELISA, immunohistochemistry and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 62 kDa in size corresponding to phosphorylated Pdcd4 protein by western blotting in the appropriate cell lysate or extract.  This phospho-specific monoclonal antibody reacts with human Pdcd4 pS457 and shows minimal reactivity by ELISA against the non-phosphorylated form of the immunizing peptide.
    Kommentare

    Gene Name: PDCD4

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
    Haltbarkeit
    12 months
  • Huang, Wu, Loeb, Hsu, Heidersbach, Brincat, Horiuchi, Lebbink, Mo, Goga, McManus: "Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion." in: The Journal of biological chemistry, Vol. 284, Issue 27, pp. 18515-24, (2009) (PubMed).

    Jansen, Camalier, Colburn: "Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis." in: Cancer research, Vol. 65, Issue 14, pp. 6034-41, (2005) (PubMed).

  • Target
    PDCD4 (Programmed Cell Death 4 (PDCD4))
    Andere Bezeichnung
    Pdcd4 (PDCD4 Produkte)
    Synonyme
    H731 antikoerper, D19Ucla1 antikoerper, Ma3 antikoerper, Tis antikoerper, Dug antikoerper, cb45 antikoerper, pdcd4 antikoerper, sb:cb45 antikoerper, wu:fc84b08 antikoerper, h731 antikoerper, MGC69337 antikoerper, PDCD4 antikoerper, wu:fa55g03 antikoerper, wu:fb08a11 antikoerper, wu:fe01a02 antikoerper, zgc:66311 antikoerper, programmed cell death 4 antikoerper, programmed cell death 4b antikoerper, programmed cell death 4 L homeolog antikoerper, programmed cell death 4 (neoplastic transformation inhibitor) antikoerper, programmed cell death 4a antikoerper, PDCD4 antikoerper, Pdcd4 antikoerper, pdcd4b antikoerper, pdcd4.L antikoerper, pdcd4 antikoerper, pdcd4a antikoerper
    Hintergrund
    Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphoryl-ation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun. Ideal for researchers involved in Cell Signaling, Cancer and Signal Transduction research.
    Synonyms: Death up-regulated gene protein antibody, Dug antibody, H731 antibody, Ma3 antibody, Neoplastic transformation inhibitor antibody, Neoplastic transformation inhibitor protein antibody, Nuclear antigen H731 antibody
    Gen-ID
    27250, 21735596
    UniProt
    Q53EL6
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