PPP2CA Antikörper (meLys309)

Produktnummer ABIN1042659

Produktdetails anti-PPP2CA Antikörper

Target: PPP2CA (Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA))

Bindungsspezifität: meLys309

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PPP2CA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Sequenz: KLH-C-ßA-RRTPDYFL-OMe

Spezifität: Recognises specifically the C-terminally methylated form of PP2A C subunit

Kreuzreaktivität: Saccharomyces cerevisiae

Kreuzreaktivität (Details): Mouse, Rat, Human. Predicted to work with: Saccharomyces cerevisiae

Aufreinigung: Protein G

Immunogen: A KLH-coupled peptide with the sequence: KLH-C-ßA-RRTPDYFL-OMe. The c-terminal sequence (as well as the carboxy-methylation) is absolutely conserved from human, mouse to yeast

Klon: 2A10

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal antibody dilution should be determined by titration, however as a guideline try, WB: 1,500. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa)

Kommentare:

Myeloma, fusion partners: X63-Ag8.653

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Purified antibody (from supernatant) containing PBS + 0.1 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Referenzen für anti-PPP2CA Antikörper (ABIN1042659)

Benziane, Björnholm, Pirkmajer, Austin, Kotova, Viollet, Zierath, Chibalin: "Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells." in: The Journal of biological chemistry, Vol. 287, Issue 28, pp. 23451-63, (2012) (PubMed).

Li, Huang, Liang, Fu, Guo, Xu: "Microcystin-LR (MCLR) induces a compensation of PP2A activity mediated by ?4 protein in HEK293 cells." in: International journal of biological sciences, Vol. 7, Issue 6, pp. 740-52, (2011) (PubMed).

Finnegan, Mackey, Cotter: "A stress survival response in retinal cells mediated through inhibition of the serine/threonine phosphatase PP2A." in: The European journal of neuroscience, Vol. 32, Issue 3, pp. 322-34, (2010) (PubMed).

Hombauer, Weismann, Mudrak, Stanzel, Fellner, Lackner, Ogris: "Generation of active protein phosphatase 2A is coupled to holoenzyme assembly." in: PLoS biology, Vol. 5, Issue 6, pp. e155, (2007) (PubMed).

Sontag, Nunbhakdi-Craig, Sontag, Diaz-Arrastia, Ogris, Dayal, Lentz, Arning, Bottiglieri: "Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 11, pp. 2751-9, (2007) (PubMed).

Sontag, Hladik, Montgomery, Luangpirom, Mudrak, Ogris, White: "Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis." in: Journal of neuropathology and experimental neurology, Vol. 63, Issue 10, pp. 1080-91, (2004) (PubMed).

Sontag, Luangpirom, Hladik, Mudrak, Ogris, Speciale, White: "Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology." in: Journal of neuropathology and experimental neurology, Vol. 63, Issue 4, pp. 287-301, (2004) (PubMed).

Fellner, Lackner, Hombauer, Piribauer, Mudrak, Zaragoza, Juno, Ogris: "A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo." in: Genes & development, Vol. 17, Issue 17, pp. 2138-50, (2003) (PubMed).

Details zu PPP2CA

Target: PPP2CA (Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA))

Andere Bezeichnung: PP2A alpha (PPP2CA Produkte)

Synonyme: PP2Ac antikoerper, PP2CA antikoerper, PP2Calpha antikoerper, RP-C antikoerper, PP2A antikoerper, R75353 antikoerper, Pp2a1 antikoerper, pp2ac antikoerper, zgc:110641 antikoerper, protein phosphatase 2 catalytic subunit alpha antikoerper, protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform antikoerper, protein phosphatase 2, catalytic subunit, alpha isozyme antikoerper, protein phosphatase 2 catalytic subunit alpha L homeolog antikoerper, protein phosphatase 2, catalytic subunit, beta isozyme antikoerper, serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform antikoerper, PPP2CA antikoerper, Ppp2ca antikoerper, ppp2ca.L antikoerper, ppp2cb antikoerper, LOC471633 antikoerper, ppp2ca antikoerper

Hintergrund: Synonyms:
PP2A alpha antibody,PP2A C antibody,PP2A-alpha antibody,PP2AA_HUMAN antibody,PP2Ac antibody,PP2CA antibody,PPP2CA antibody,Protein phosphatase 2, catalytic subunit, alpha isoform antibody,Replication protein C antibody

Gen-ID: 5515, 19052, 24672

OMIM: 176915

UniProt: P67775, P63330, P63331

Pathways: PI3K-Akt Signalweg, Mitotic G1-G1/S Phases, Hepatitis C, Toll-Like Receptors Cascades