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Produktdetails

anti-matrix metalloprotease 1 (MMP1) Antikörper

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Bild für anti-matrix metalloprotease 1 (MMP1) Antikörper
Antigen: Matrix metalloprotease 1 (MMP1)
Klonalität: Polyklonal
Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Reaktivität: Human
Wirt: Rabbit
1 Publikation vorhanden 1 Publikation vorhanden
Menge: 1ml (100ug/ml approximately) (Produktvarianten)
Preis: 466,30 €   (Zzgl. Versandkosten und MWSt)
Bestellnummer: ABIN103982
Verfügbarkeit: Lieferbar innerhalb von 5 Werktagen
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Produktbeschreibung  » anti-matrix metalloprotease 1 (MMP1) Antikörper

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Antigen Matrix metalloprotease 1 (MMP1)
Immunogen A synthetic peptide from the middle region of the human MMP-1.
Reaktivität Human
Klonalität Polyklonal
Format Ig-fraction, Purified
Wirt Rabbit
Spezifität This antibody reacts with a 52 kD protein (unglycosylated) and 57 kD (glycosylated) species of pro form of MMP-1 as well as 42 kD (unglycosylated) and 47 kD (glycosylated) active form of MMP-1. Matrix metalloproteinase (MMPs) are a family of closely related zinc-containing proteolytic enzymes, capable of degrading connective tissue components. MMP-1 appears to be associated with facilitating the tumor spread and invasion of esophageal and colorectal cancers and is associated with poor prognosis. Interstitial collagenase (MMP-1), 73 kD gelatinase A/type IV collagenase (MMP-2) and 92 kD gelatinase B/type IV collagenase (MMP-9) dissolve extracellular matrix and may initiate and promote angiogenesis.

Anwendungen  » anti-matrix metalloprotease 1 (MMP1) Antikörper

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Applikation Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
» Hier finden Sie 1 verfügbares Protokoll zu den getesteten Anwendungen
Applikationshinweise Titer/Working Dilution: This antibody may be diluted to a titer of 1:25-1:50 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Staining Protocol: We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation conditions should be determined by the user. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Positive Control: Placenta. Cellular localization: Cytoplasmic
Konzentration 100ug/ml approximately
Buffer Purified immunoglobulin fraction of rabbit antiserum against MMP-1 containing sodium azide as preservative.
Lagerung Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.
Forschungsgebiet Extrazelluläre Matrix
Beschränkungen Für Forschungszwecke. Als CE-zertifizierter Antikörper in der Europäischen Union für In Vitro Diagnostik (IVD) zugelassen.

Publikationen  » anti-matrix metalloprotease 1 (MMP1) Antikörper

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Publikationen Windsor, Birkedal-Hansen, Birkedal-Hansen et al.: "An internal cysteine plays a role in the maintenance of the latency of human fibroblast collagenase." In: Biochemistry , Vol. 30, Issue 3, pp. 641-7, 1991 (PubMed)