anti-Matrix Metalloproteinase 1 (MMP1) antibody

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	Antigen:	Matrix Metalloproteinase 1 (MMP1)
	Klonalität:	Polyklonal
	Applikation:	Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
	Reaktivität:	Human
	Wirt:	Rabbit
		1 Publikation vorhanden
	Menge:	1ml (100ug/ml approximately) (Produktvarianten)
	Preis:	464,00 $ (Zzgl. Versandkosten $25 und MWSt, Invoice in EUR)
	Bestellnummer:	ABIN103982
	Verfügbarkeit:	Lieferbar innerhalb von 5 Werktagen

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Produktbeschreibung » anti-Matrix Metalloproteinase 1 (MMP1) antibody

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Antigen	Matrix Metalloproteinase 1 (MMP1)
Immunogen	A synthetic peptide from the middle region of the human MMP-1.
Reaktivität	Human
Klonalität	Polyklonal
Format	Ig Fraction, Purified
Wirt	Rabbit
Spezifität	This antibody reacts with a 52 kD protein (unglycosylated) and 57 kD (glycosylated) species of pro form of MMP-1 as well as 42 kD (unglycosylated) and 47 kD (glycosylated) active form of MMP-1. Matrix metalloproteinase (MMPs) are a family of closely related zinc-containing proteolytic enzymes, capable of degrading connective tissue components. MMP-1 appears to be associated with facilitating the tumor spread and invasion of esophageal and colorectal cancers and is associated with poor prognosis. Interstitial collagenase (MMP-1), 73 kD gelatinase A/type IV collagenase (MMP-2) and 92 kD gelatinase B/type IV collagenase (MMP-9) dissolve extracellular matrix and may initiate and promote angiogenesis.

Anwendungen » anti-Matrix Metalloproteinase 1 (MMP1) antibody

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Applikation	Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) » Hier finden Sie 1 verfügbares Protokoll zu den getesteten Anwendungen
Applikationshinweise	Titer/Working Dilution: This antibody may be diluted to a titer of 1:25-1:50 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Staining Protocol: We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation conditions should be determined by the user. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Positive Control: Placenta. Cellular localization: Cytoplasmic
Konzentration	100ug/ml approximately
Buffer	Purified immunoglobulin fraction of rabbit antiserum against MMP-1 containing sodium azide as preservative.
Lagerung	Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.
Forschungsgebiet	Extracellular Matrix
Beschränkungen	Für Forschungszwecke. Als CE-zertifizierter Antikörper in der Europäischen Union für In Vitro Diagnostik (IVD) zugelassen.

Publikationen » anti-Matrix Metalloproteinase 1 (MMP1) antibody

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Publikationen

Windsor, Birkedal-Hansen, Birkedal-Hansen et al.: "An internal cysteine plays a role in the maintenance of the latency of human fibroblast collagenase." In: Biochemistry , Vol. 30, Issue 3, pp. 641-7, 1991 (PubMed)