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AMPK activation reduces the formation of atheromata-inducing macrophages in ApoE(-/-)-deficient mice by inhibiting expression of Ccr2, thereby preventing the Ccr2-mediated migration of Ly6C(hi) monocytes from the bone marrow.
Data show that AMPKalpha1 protects mice from diet-induced obesity and insulin (zeige INS Proteine) resistance.
Thus we concluded that the AMPKalpha (zeige GRK4 Proteine)-SIRT1 (zeige SIRT1 Proteine) molecular pathway may be a molecular mechanism of IR in PCOS and may serve as a therapeutic target for the development of potential treatments for improving metabolic and reproductive function in PCOS.
AMPK activation inhibited IL-1beta (zeige IL1B Proteine)-stimulated CXCL10 (zeige CXCL10 Proteine) secretion, associated with reduced interleukin-1 receptor associated kinase-4 (IRAK4 (zeige IRAK4 Proteine)) phosphorylation.
Findings indicate that the energy-sensing LKB1 (zeige STK11 Proteine)-AMPK pathway regulates IGF1 (zeige IGF1 Proteine) secretion in mouse primary hepatocytes, which in turn regulates activation of the IGF1R (zeige IGF1R Proteine)-PKB (zeige AKT2 Proteine) pathway.
These data suggest that nutrient availability dictates the mode of division and that LKB1 (zeige STK11 Proteine)-AMPK mediates this nutrient-driven effect on intestinal epithelial stem cell proliferation.
Myeloid-Restricted AMPKalpha1 Promotes Host Immunity and Protects against IL-12 (zeige IL12A Proteine)/23p40-Dependent Lung Injury during Hookworm Infection
Data suggest that Il4 (zeige IL4 Proteine) (usually released from helper T-cells) induces Cox1 in macrophages at post-transcriptional level; activation of Ampk (catalytic subunit Prkaa1) by metformin blocks Il4 (zeige IL4 Proteine)-dependent induction of Cox1 and blocks macrophage polarization/activation. (Il4 (zeige IL4 Proteine) = interleukin-4 (zeige IL4 Proteine); Cox1 = cyclooxygenase 1 (zeige PTGS1 Proteine); Ampk = AMP-activated protein kinase (zeige PRKAA2 Proteine))
The metformin-rescued P23H rhodopsin was still intrinsically unstable and led to increased structural instability of the rod outer segments. These data suggest that improving the traffic of misfolding rhodopsin mutants is unlikely to be a practical therapy, but also highlights the potential of altering translation through AMPK to improve protein function in other protein misfolding diseases
Mechanistically, miR (zeige MLXIP Proteine)-499 directly targets Fnip1, an AMP-activated protein kinase (AMPK (zeige PRKAA2 Proteine))-interacting protein that negatively regulates AMPK, a known activator of PGC-1alpha. This miR (zeige MLXIP Proteine)-499/Fnip1/AMPK circuit can serve as a mechanism to couple muscle fiber type and mitochondrial function.
Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK (zeige PRKAA2 Proteine)).
The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.
Nitrated oleic acid activates AMPK in endothelial cells.
Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter (zeige SLC12A1 Proteine) involves activation of AMPK.
Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.
the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS (zeige NOS3 Proteine)
Thus novel NM23-H1/NDPK A (zeige NME1 Proteine)-dependent regulation of AMPK alpha1-mediated phosphorylation is present in mammalian cells.
As in patients with PRKAG2 (zeige PRKAG2 Proteine) cardiomyopathy, iPS (zeige SLC27A4 Proteine) cell and mouse models are protected from cardiac fibrosis, and we define a crosstalk between AMPK and post-transcriptional regulation of TGFbeta (zeige TGFB1 Proteine) isoform signaling that has implications in fibrotic forms of cardiomyopathy.
findings provide new insights into previously underappreciated metabolic regulatory roles of HDAC1 (zeige HDAC1 Proteine) in coordinating nutrient availability and cellular responses upstream of AMPK
this work establishes the role of host AMPK signaling as a suppressive pathway of Plasmodium hepatic infection and as a potential target for host-based antimalarial interventions.
GN administration rescued the decreased phosphorylation of AMPK and Akt (zeige AKT1 Proteine) and stimulated the expression of mitochondria biogenesis genes in the skeletal muscle of HFD mice. These findings suggested that GN exerted anti-hyperglycemic effects through AMPK activation.
Our results indicated that H. pylori infection, CagA (zeige S100A8 Proteine) status, and PRKAA1 polymorphisms were risk factors for gastric cancer in Koreans, and that the combination of two of these factors rather than their independent effects synergistically increased the risk.
Taken together, these data indicated that adiponectin promotes endothelial progenitor cell proliferation and migration via AMPK/Akt/eNOS signaling pathway and promotes tube formation through AMPK/eNOS, suggesting that adiponectin-transduced endothelial progenitor cell transplantation is a potential therapeutic target for vascular disease.
We will also describe distinct crossroads between the regulation of longevity and cancer, e.g. specific regulation through the AMPKalpha (zeige GRK4 Proteine) and HIF-alpha isoforms, the Warburg effect, mitochondrial dynamics, and cellular senescence. [review]
AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.
Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.
NDPK-A (zeige NME1 Proteine) exists in a functional cellular complex with AMPK (zeige PRKAA2 Proteine) and CFTR (zeige CFTR Proteine) in airway epithelia, and NDPK-A (zeige NME1 Proteine) catalytic function is required for the AMPK (zeige PRKAA2 Proteine)-dependent regulation of CFTR (zeige CFTR Proteine)
Klotho (zeige KL Proteine) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (zeige GRK4 Proteine)-RUNX2 (zeige RUNX2 Proteine) pathway.
AMPK-mTOR (zeige FRAP1 Proteine)-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR (zeige MYLIP Proteine)-1285 and thus activating AMP-activated protein kinase (AMPK (zeige PRKAA2 Proteine)).
L-Glutamine enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.
AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.
AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK (zeige MAPK1 Proteine)/TSC2/mTOR (zeige FRAP1 Proteine) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.
AMPK functions to inhibit IGF-I (zeige IGF1 Proteine)-stimulated PI3K pathway activation through stimulation of IRS-1 (zeige IRS1 Proteine) serine 794 phosphorylation.
acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
5'-AMP-activated protein kinase catalytic subunit alpha-1
, 5'-AMP-activated protein kinase, catalytic alpha-1 chain
, ACACA kinase
, AMP -activate kinase alpha 1 subunit
, AMP-activated protein kinase, catalytic, alpha-1
, AMPK alpha 1
, AMPK subunit alpha-1
, HMGCR kinase
, acetyl-CoA carboxylase kinase
, hydroxymethylglutaryl-CoA reductase kinase
, tau-protein kinase PRKAA1
, 5'-AMP-activated protein kinase alpha-1 catalytic subunit
, 5'-AMP-activated protein kinase alpha 1 catalytic subunit
, 63 kDa subunit
, AMPK 63 kDa subunit
, AMPK alpha-1 chain
, AMP-activated protein kinase, alpha 1 catalytic subunit
, 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein
, AMPK-activated protein kinase alpha-1 subunit
, protein kinase, AMP-activated, alpha 1 catalytic subunit