Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Select your species
AMPK activation inhibited IL-1beta (zeige IL1B ELISA Kits)-stimulated CXCL10 (zeige CXCL10 ELISA Kits) secretion, associated with reduced interleukin-1 receptor associated kinase-4 (IRAK4 (zeige IRAK4 ELISA Kits)) phosphorylation.
Findings indicate that the energy-sensing LKB1 (zeige STK11 ELISA Kits)-AMPK pathway regulates IGF1 (zeige IGF1 ELISA Kits) secretion in mouse primary hepatocytes, which in turn regulates activation of the IGF1R (zeige IGF1R ELISA Kits)-PKB (zeige AKT2 ELISA Kits) pathway.
These data suggest that nutrient availability dictates the mode of division and that LKB1 (zeige STK11 ELISA Kits)-AMPK mediates this nutrient-driven effect on intestinal epithelial stem cell proliferation.
Myeloid-Restricted AMPKalpha1 Promotes Host Immunity and Protects against IL-12 (zeige IL12A ELISA Kits)/23p40-Dependent Lung Injury during Hookworm Infection
Data suggest that Il4 (zeige IL4 ELISA Kits) (usually released from helper T-cells) induces Cox1 (zeige COX1 ELISA Kits) in macrophages at post-transcriptional level; activation of Ampk (catalytic subunit Prkaa1) by metformin blocks Il4 (zeige IL4 ELISA Kits)-dependent induction of Cox1 (zeige COX1 ELISA Kits) and blocks macrophage polarization/activation. (Il4 (zeige IL4 ELISA Kits) = interleukin-4 (zeige IL4 ELISA Kits); Cox1 (zeige COX1 ELISA Kits) = cyclooxygenase 1 (zeige PTGS1 ELISA Kits); Ampk = AMP-activated protein kinase (zeige PRKAA2 ELISA Kits))
The metformin-rescued P23H rhodopsin (zeige RHO ELISA Kits) was still intrinsically unstable and led to increased structural instability of the rod outer segments. These data suggest that improving the traffic of misfolding rhodopsin (zeige RHO ELISA Kits) mutants is unlikely to be a practical therapy, but also highlights the potential of altering translation through AMPK to improve protein function in other protein misfolding diseases
Mechanistically, miR (zeige MLXIP ELISA Kits)-499 directly targets Fnip1 (zeige FNIP1 ELISA Kits), an AMP-activated protein kinase (AMPK (zeige PRKAA2 ELISA Kits))-interacting protein that negatively regulates AMPK, a known activator of PGC-1alpha (zeige PPARGC1A ELISA Kits). This miR (zeige MLXIP ELISA Kits)-499/Fnip1 (zeige FNIP1 ELISA Kits)/AMPK circuit can serve as a mechanism to couple muscle fiber type and mitochondrial function.
dopamine is coupled to AMPK activation, which provides a substantial anti-inflammatory and bioenergetic advantage and reduces the severity of endotoxin-induced acute lung injury.
AMPKalpha1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development.
mitochondrial dysfunction triggers LKB1 (zeige STK11 ELISA Kits)-mediated AMPK activation, which stimulates Sirt2 (zeige SIRT2 ELISA Kits) phosphorylation, leading to activation of mTOR (zeige FRAP1 ELISA Kits)-RAPTOR (zeige RPTOR ELISA Kits) and Glut1 (zeige SLC2A1 ELISA Kits)-mediated glucose uptake.
Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK (zeige PRKAA2 ELISA Kits)).
The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.
Nitrated oleic acid activates AMPK in endothelial cells.
Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter (zeige SLC12A1 ELISA Kits) involves activation of AMPK.
Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.
the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS (zeige NOS3 ELISA Kits)
Our results indicated that H. pylori infection, CagA (zeige S100A8 ELISA Kits) status, and PRKAA1 polymorphisms were risk factors for gastric cancer in Koreans, and that the combination of two of these factors rather than their independent effects synergistically increased the risk.
Taken together, these data indicated that adiponectin promotes endothelial progenitor cell proliferation and migration via AMPK/Akt/eNOS signaling pathway and promotes tube formation through AMPK/eNOS, suggesting that adiponectin-transduced endothelial progenitor cell transplantation is a potential therapeutic target for vascular disease.
We will also describe distinct crossroads between the regulation of longevity and cancer, e.g. specific regulation through the AMPKalpha (zeige GRK4 ELISA Kits) and HIF-alpha isoforms, the Warburg effect, mitochondrial dynamics, and cellular senescence. [review]
These results suggest that the LKB1 (zeige STK11 ELISA Kits)-AMPK-FoxO1 (zeige FOXO1 ELISA Kits) signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.
this study shows taht AMPK reduces abnormal inflammatory responses and cellular senescence, which implicates as a potential therapeutic target for chronic obstructive pulmonary disease/emphysema
Salusin-beta mediates high glucose-induced endothelial injury via disruption of AMPK signaling pathway.
These findings identify a key mechanism of tolerance to Ras-Raf (zeige RAF1 ELISA Kits) pathway inhibitors and suggest that blocking either AMPK or autophagy in combination with these targeted inhibitors could increase tumor regression and decrease the likelihood of eventual recurrence.
the Runx2 (zeige RUNX2 ELISA Kits) knockdown cells displayed activation of AMP-activated protein kinase (AMPKalpha (zeige GRK4 ELISA Kits)), the sensor of cellular metabolism. Importantly, the Runx2 (zeige RUNX2 ELISA Kits) knockdown in bone-derived cells resulted in increased sensitivity to both Erk1/2 (zeige MAPK1/3 ELISA Kits) inhibition and AMPKalpha (zeige GRK4 ELISA Kits) activation by PD184161 and metformin, respectively, despite increased IGF-1Rbeta and AMPKalpha (zeige GRK4 ELISA Kits) levels.
AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.
Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.
NDPK-A (zeige NME1 ELISA Kits) exists in a functional cellular complex with AMPK (zeige PRKAA2 ELISA Kits) and CFTR (zeige CFTR ELISA Kits) in airway epithelia, and NDPK-A (zeige NME1 ELISA Kits) catalytic function is required for the AMPK (zeige PRKAA2 ELISA Kits)-dependent regulation of CFTR (zeige CFTR ELISA Kits)
Klotho (zeige KL ELISA Kits) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (zeige GRK4 ELISA Kits)-RUNX2 (zeige RUNX2 ELISA Kits) pathway.
AMPK-mTOR (zeige FRAP1 ELISA Kits)-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR (zeige MYLIP ELISA Kits)-1285 and thus activating AMP-activated protein kinase (AMPK (zeige PRKAA2 ELISA Kits)).
L-Glutamine enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.
AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.
AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK (zeige MAPK1 ELISA Kits)/TSC2 (zeige TSC2 ELISA Kits)/mTOR (zeige FRAP1 ELISA Kits) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.
AMPK functions to inhibit IGF-I (zeige IGF1 ELISA Kits)-stimulated PI3K pathway activation through stimulation of IRS-1 (zeige IRS1 ELISA Kits) serine 794 phosphorylation.
acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
5'-AMP-activated protein kinase catalytic subunit alpha-1
, 5'-AMP-activated protein kinase, catalytic alpha-1 chain
, ACACA kinase
, AMP -activate kinase alpha 1 subunit
, AMP-activated protein kinase, catalytic, alpha-1
, AMPK alpha 1
, AMPK subunit alpha-1
, HMGCR kinase
, acetyl-CoA carboxylase kinase
, hydroxymethylglutaryl-CoA reductase kinase
, tau-protein kinase PRKAA1
, 5'-AMP-activated protein kinase alpha-1 catalytic subunit
, 5'-AMP-activated protein kinase alpha 1 catalytic subunit
, 63 kDa subunit
, AMPK 63 kDa subunit
, AMPK alpha-1 chain
, AMP-activated protein kinase, alpha 1 catalytic subunit
, 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein
, AMPK-activated protein kinase alpha-1 subunit
, protein kinase, AMP-activated, alpha 1 catalytic subunit