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Here the authors report that loss of Drosophila HNF4 recapitulates hallmark symptoms of Maturity Onset Diabetes of the Young 1 (MODY1), including adult-onset hyperglycemia, glucose intolerance and impaired glucose-stimulated insulin (zeige INS ELISA Kits) secretion (GSIS).
Drosophila HNF4 mutants display diabetic phenotypes similar to those of sir2 (zeige SIRT1 ELISA Kits) mutants, and protein levels for dHNF4 are reduced in sir2 (zeige SIRT1 ELISA Kits) mutant animals. Sir2 (zeige SIRT1 ELISA Kits) exerts these effects by deacetylating and stabilizing dHNF4 through protein interactions.
Results support a feed-forward model for dHNF4, in which fatty acids released from triglycerides activate the receptor, inducing enzymes that drive fatty acid oxidation for energy production.
In summary, HNF4alpha isoforms perform non-redundant functions in the colon under conditions of stress, underscoring the importance of tracking them both in colitis and colon cancer.
Hnf4alpha silencing with shRNA transfection into auditory neuroblast cells (VOT-33) reduced cell viability
both iron-dextran injection and a 3% carbonyl iron-containing diet led to upregulation of hepatic inflammation, which was associated with a significant reduction in HNF4alpha expression and its downstream target, miR (zeige MLXIP ELISA Kits)-122.
Tg737 (zeige IFT88 ELISA Kits) regulates a Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits)/Snail (zeige SNAI1 ELISA Kits)-HNF4alpha negative feedback circuit, thereby blocking EMT (zeige ITK ELISA Kits) and the malignant transformation of liver stem cells to liver cancer stem cells.
Down regulation of HNF4 alpha plays a role in metabolic liver function and the pathogenesis of liver cancer.
A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 (zeige CDX2 ELISA Kits) and HNF4alpha were ectopically expressed by adenoviral infection. We demonstrate the expression of CDX2 (zeige CDX2 ELISA Kits) and HNF4alpha in human biopsy samples.
Fibrotic levels of matrix stiffness significantly inhibit hepatocyte-specific functions in part by inhibiting the HNF4alpha transcriptional network mediated through the Rho/Rho-associated protein kinase pathway.
key role in controlling hepatic CES2 expression in diabetes, obesity, or nonalcoholic steatohepatitis
These findings reveal a novel HNF4alpha network controlled by miR (zeige MLXIP ELISA Kits)-194/192 that may play a critical role in maintaining the hepatocyte-differentiated state by inhibiting expression of genes involved in dedifferentiation and tumorigenesis.
HNF4alpha regulates homeostatic proliferation in the gastric epithelium and is both necessary and sufficient for the upstream regulation of the Xbp1-->Mist1 axis in maintenance of zymogen cell secretory architecture.
Transplantation of HNF4A overexpressing immortalized human hepatocytes (IHH (zeige IHH ELISA Kits)) resulted in better liver function and survival of rats with acute liver failure (ALF (zeige GTF2A1L ELISA Kits)) compared with IHH (zeige IHH ELISA Kits). HNF4A improved hepatic differentiation of IHH (zeige IHH ELISA Kits). Transplantation of HNF4A-overexpressing IHH (zeige IHH ELISA Kits) could improve the liver function and survival in a rat model of ALF (zeige GTF2A1L ELISA Kits).
Analysis of differential gene expression between mesenchymal and epithelial cancer cell lines revealed that hepatocyte nuclear factor 4alpha (HNF4alpha), a transcriptional activator of intestinal (epithelial) differentiation, and its target genes are highly expressed in epithelial cancer cell lines
data suggest that the ERK1/2 (zeige MAPK1/3 ELISA Kits) pathway plays an important role in the regulation of HNF4alpha-dependent hepatic gene expression.
HNF4alpha upregulated the expression of liver glutaminase 2 (zeige GLS2 ELISA Kits) in HepG2 cells
The Mexican genome-wide association study signal for high serum triglycerides on chromosome 18q11.2 harbors a regulatory single-nucleotide polymorphism, rs17259126, which disrupts normal hepatocyte nuclear factor 4 alpha binding and decreases the expression of the regional TMEM241 gene. Our data suggest that decreased transcript levels of TMEM241 contribute to increased triglyceride levels in Mexicans.
The HNF4alpha-knockdown-induced stimulation of hepcidin could be entirely blocked when BMPR1A was interfered with at the same time.
Direct induction of hepatocyte-like cells from immortalized human bone marrow mesenchymal stem cells by overexpression of HNF4a has been reported.
Data redefine p.R114W as a pathogenic mutation that causes a distinct clinical subtype of HNF4A MODY with reduced penetrance, reduced sensitivity to sulfonylurea treatment, and no effect on birth weight.
HNF4 positively regulates pUPII gene promoter activity.
Tetra-primer ARMS-PCR identifies the novel genetic variations of bovine HNF-4alpha gene associating with growth traits.
Results show that chicken ovalbumin upstream promoter transcription factor (zeige NR2F1 ELISA Kits) II (COUP-TFII (zeige NR2F2 ELISA Kits)), hepatocyte nuclear factor 4alpha (HNF-4alpha) and HNF-4gamma regulate growth hormone receptor (zeige GHR ELISA Kits) 1A promoter activity through binding to a common DNA element
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.
hepatocyte nuclear factor 4 alpha
, hepatocyte nuclear factor 4, alpha
, hepatocyte nuclear factor 4-alpha-like
, hepatocyte nuclear factor 4-alpha
, hepatocyte nuclear factor 4
, hepatocyte nuclear factor 4 homologue
, HNF4 alpha
, Nuclear receptor 2A1
, nuclear receptor subfamily 2 group A member 1
, transcription factor 14
, transcription factor HNF-4
, alpha transcription factor 4
, hepatic nuclear factor 4, alpha
, hepatic nuclear factor 4 alpha
, hepatic nuclear factor 4
, hepatic nuclear factor 4alpha
, nuclear receptor