anti-HNF4A (HNF4A) Antikörper

Bezeichnung:
anti-Hepatocyte Nuclear Factor 4, alpha Antikörper (HNF4A)
Auf www.antikoerper-online.de finden Sie aktuell 196 Hepatocyte Nuclear Factor 4, alpha (HNF4A) Antikörper von 28 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen HNF4A Kits (23) und HNF4A Proteine (13) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 250 HNF4A Produkte verfügbar.
Synonyme:
CG9310, dHNF-4, dHNF4, Dmel\\CG9310, DmHNF4, fb58h09, Hnf-4, HNF-4(D), HNF-4alpha, Hnf-4h, hnf4, HNF4A, HNF4a7, HNF4a8, HNF4a9, Hnf4alpha, id:ibd1279, MODY, MODY1, nr2a1, NR2A4, NR2A21, TCF, TCF14, wu:fb58h09

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anti-Mouse (Murine) HNF4A Antikörper:

anti-Rat (Rattus) HNF4A Antikörper:

anti-Human HNF4A Antikörper:

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Am meisten referenzierte anti-HNF4A Antikörper

  1. Human Monoclonal HNF4A Primary Antibody für IF, WB - ABIN394242 : Jablonski, McAteer, de Bakker, Franks, Pollin, Hanson, Saxena, Fowler, Shuldiner, Knowler, Altshuler, Florez: Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. in Diabetes 2010 (PubMed)
    Zeige alle 5 Referenzen für 394242

  2. Cow (Bovine) Polyclonal HNF4A Primary Antibody für WB - ABIN2777514 : Weedon, Owen, Shields, Hitman, Walker, McCarthy, Love-Gregory, Permutt, Hattersley, Frayling: Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population. in Diabetes 2004 (PubMed)
    Zeige alle 4 Referenzen für 2777514

  3. Human Polyclonal HNF4A Primary Antibody für EIA, WB - ABIN357940 : Lee, Cha, Jung, Shon, Kim, Yeo, Shin: Genetic polymorphism of hepatocyte nuclear factor-4alpha influences human cytochrome P450 2D6 activity. in Hepatology (Baltimore, Md.) 2008 (PubMed)
    Zeige alle 3 Referenzen für 357940

  4. Human Polyclonal HNF4A Primary Antibody für EIA, IF - ABIN952766 : Lundblad, Eliasson: Silent myocardial infarction in women with impaired glucose tolerance: the Northern Sweden MONICA study. in Cardiovascular diabetology 2005 (PubMed)
    Zeige alle 2 Referenzen für 952766

  5. Human Polyclonal HNF4A Primary Antibody für ELISA, WB - ABIN185378 : Damcott, Hoppman, Ott, Reinhart, Wang, Pollin, OConnell, Mitchell, Shuldiner: Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish. in Diabetes 2004 (PubMed)

  6. Human Polyclonal HNF4A Primary Antibody für IF, WB - ABIN653385 : Hong, Varanasi, Yang, Leff: AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability. in The Journal of biological chemistry 2003 (PubMed)

  7. Cow (Bovine) Polyclonal HNF4A Primary Antibody für WB - ABIN2782264 : Holmkvist, Almgren, Lyssenko, Lindgren, Eriksson, Isomaa, Tuomi, Nilsson, Groop: Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes. in Diabetes 2008 (PubMed)

  8. Human Polyclonal HNF4A Primary Antibody für FACS, IF - ABIN389269 : Furuta, Iwasaki, Oda, Hinokio, Horikawa, Yamagata, Yano, Sugahiro, Ogata, Ohgawara, Omori, Iwamoto, Bell: Organization and partial sequence of the hepatocyte nuclear factor-4 alpha/MODY1 gene and identification of a missense mutation, R127W, in a Japanese family with MODY. in Diabetes 1997 (PubMed)

Weitere Antikörper gegen HNF4A Interaktionspartner

Fruit Fly (Drosophila melanogaster) Hepatocyte Nuclear Factor 4, alpha (HNF4A) Interaktionspartner

  1. Drosophila HNF4 mutants display diabetic phenotypes similar to those of sir2 (zeige SIRT1 Antikörper) mutants, and protein levels for dHNF4 are reduced in sir2 (zeige SIRT1 Antikörper) mutant animals. Sir2 (zeige SIRT1 Antikörper) exerts these effects by deacetylating and stabilizing dHNF4 through protein interactions.

  2. Results support a feed-forward model for dHNF4, in which fatty acids released from triglycerides activate the receptor, inducing enzymes that drive fatty acid oxidation for energy production.

Mouse (Murine) Hepatocyte Nuclear Factor 4, alpha (HNF4A) Interaktionspartner

  1. Down regulation of HNF4 alpha plays a role in metabolic liver function and the pathogenesis of liver cancer.

  2. A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 (zeige CDX2 Antikörper) and HNF4alpha were ectopically expressed by adenoviral infection. We demonstrate the expression of CDX2 (zeige CDX2 Antikörper) and HNF4alpha in human biopsy samples.

  3. Fibrotic levels of matrix stiffness significantly inhibit hepatocyte-specific functions in part by inhibiting the HNF4alpha transcriptional network mediated through the Rho/Rho-associated protein kinase pathway.

  4. key role in controlling hepatic CES2 expression in diabetes, obesity, or nonalcoholic steatohepatitis

  5. These findings reveal a novel HNF4alpha network controlled by miR (zeige MLXIP Antikörper)-194/192 that may play a critical role in maintaining the hepatocyte-differentiated state by inhibiting expression of genes involved in dedifferentiation and tumorigenesis.

  6. HNF4alpha regulates homeostatic proliferation in the gastric epithelium and is both necessary and sufficient for the upstream regulation of the Xbp1-->Mist1 axis in maintenance of zymogen cell secretory architecture.

  7. These results suggest that down-regulation of HNF4alpha could be of importance in beta-cell dysfunction by hypoxia.

  8. Hnf4a expression during embryonic stem cell differentiation

  9. Cyp1b1 (zeige CYP1B1 Antikörper) affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4alpha and PPARalpha (zeige PPARA Antikörper).

  10. HNF-4alpha regulated miR (zeige MLXIP Antikörper)-122 contributes to development of the gluconeogenic and lipid metabolism alterations observed in Type 2 diabetic mice and in palmitate-treated HepG2 cells

Human Hepatocyte Nuclear Factor 4, alpha (HNF4A) Interaktionspartner

  1. Analysis of differential gene expression between mesenchymal and epithelial cancer cell lines revealed that hepatocyte nuclear factor 4alpha (HNF4alpha), a transcriptional activator of intestinal (epithelial) differentiation, and its target genes are highly expressed in epithelial cancer cell lines

  2. A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 (zeige CDX2 Antikörper) and HNF4alpha were ectopically expressed by adenoviral infection. We demonstrate the expression of CDX2 (zeige CDX2 Antikörper) and HNF4alpha in human biopsy samples.

  3. data suggest that the ERK1/2 (zeige MAPK1/3 Antikörper) pathway plays an important role in the regulation of HNF4alpha-dependent hepatic gene expression.

  4. HNF4alpha upregulated the expression of liver glutaminase 2 (zeige GLS2 Antikörper) in HepG2 cells

  5. The Mexican genome-wide association study signal for high serum triglycerides on chromosome 18q11.2 harbors a regulatory single-nucleotide polymorphism, rs17259126, which disrupts normal hepatocyte nuclear factor 4 alpha binding and decreases the expression of the regional TMEM241 gene. Our data suggest that decreased transcript levels of TMEM241 contribute to increased triglyceride levels in Mexicans.

  6. The HNF4alpha-knockdown-induced stimulation of hepcidin (zeige HAMP PLURAL_@2248@) could be entirely blocked when BMPR1A (zeige BMPR1A PLURAL_@2248@) was interfered with at the same time.

  7. Direct induction of hepatocyte-like cells from immortalized human bone marrow mesenchymal stem cells by overexpression of HNF4a has been reported.

  8. Data redefine p.R114W as a pathogenic mutation that causes a distinct clinical subtype of HNF4A MODY with reduced penetrance, reduced sensitivity to sulfonylurea treatment, and no effect on birth weight.

  9. Renal Fanconi syndrome represents the only HNF4A feature showing complete penetrance. Our cases suggest that the p.R63W HNF4A mutation must be considered in subjects with a normal birth weight and postulate the possibility of liver involvement as a part of this condition.

  10. HNF-4alpha regulated miR (zeige MLXIP Antikörper)-122 contributes to development of the gluconeogenic and lipid metabolism alterations observed in Type 2 diabetic mice and in palmitate-treated HepG2 cells

Pig (Porcine) Hepatocyte Nuclear Factor 4, alpha (HNF4A) Interaktionspartner

  1. HNF4 positively regulates pUPII gene promoter activity.

Cow (Bovine) Hepatocyte Nuclear Factor 4, alpha (HNF4A) Interaktionspartner

  1. Tetra-primer ARMS-PCR identifies the novel genetic variations of bovine HNF-4alpha gene associating with growth traits.

  2. Results show that chicken ovalbumin upstream promoter transcription factor (zeige NR2F1 Antikörper) II (COUP-TFII (zeige NR2F2 Antikörper)), hepatocyte nuclear factor 4alpha (HNF-4alpha) and HNF-4gamma regulate growth hormone receptor (zeige GHR Antikörper) 1A promoter activity through binding to a common DNA element

HNF4A Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.

Alternative names and synonyms associated with HNF4A

  • hepatocyte nuclear factor 4, alpha (HNF4A) Antikörper
  • hepatocyte nuclear factor 4, alpha (hnf4a) Antikörper
  • Hepatocyte nuclear factor 4 (Hnf4) Antikörper
  • hepatic nuclear factor 4, alpha (Hnf4a) Antikörper
  • hepatocyte nuclear factor 4 alpha (LOC100345457) Antikörper
  • hepatocyte nuclear factor 4, alpha (Hnf4a) Antikörper
  • CG9310 Antikörper
  • dHNF-4 Antikörper
  • dHNF4 Antikörper
  • Dmel\\CG9310 Antikörper
  • DmHNF4 Antikörper
  • fb58h09 Antikörper
  • Hnf-4 Antikörper
  • HNF-4(D) Antikörper
  • HNF-4alpha Antikörper
  • Hnf-4h Antikörper
  • hnf4 Antikörper
  • HNF4A Antikörper
  • HNF4a7 Antikörper
  • HNF4a8 Antikörper
  • HNF4a9 Antikörper
  • Hnf4alpha Antikörper
  • id:ibd1279 Antikörper
  • MODY Antikörper
  • MODY1 Antikörper
  • nr2a1 Antikörper
  • NR2A4 Antikörper
  • NR2A21 Antikörper
  • TCF Antikörper
  • TCF14 Antikörper
  • wu:fb58h09 Antikörper

Bezeichner auf Proteinebene für HNF4A

hepatocyte nuclear factor 4 alpha , hepatocyte nuclear factor 4, alpha , hepatocyte nuclear factor 4-alpha-like , hepatocyte nuclear factor 4-alpha , CG9310-PA , CG9310-PB , CG9310-PD , CG9310-PE , Hnf4-PA , Hnf4-PB , Hnf4-PD , Hnf4-PE , hepatocyte nuclear factor 4 , hepatocyte nuclear factor 4 homologue , HNF-4-alpha , HNF4 alpha , HNF4alpha10 , HNF4alpha11 , HNF4alpha12 , Nuclear receptor 2A1 , TCF-14 , nuclear receptor subfamily 2 group A member 1 , transcription factor 14 , transcription factor HNF-4 , alpha transcription factor 4 , hepatic nuclear factor 4, alpha , HNF4alpha10/11/12 , hepatic nuclear factor 4 alpha , hepatic nuclear factor 4 , NR2A1 , hepatic nuclear factor 4alpha , nuclear receptor

GENE ID SPEZIES
458269 Pan troglodytes
100023834 Monodelphis domestica
100056007 Equus caballus
100402825 Callithrix jacchus
100528306 Ictalurus punctatus
100534656 Ovis aries
100593478 Nomascus leucogenys
44544 Drosophila melanogaster
15378 Mus musculus
100345457 Oryctolagus cuniculus
25735 Rattus norvegicus
3172 Homo sapiens
485884 Canis lupus familiaris
733636 Sus scrofa
509200 Bos taurus
322358 Danio rerio
379762 Xenopus laevis
100713275 Cavia porcellus
419198 Gallus gallus
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