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anti-Human ELAVL1 Antikörper:
anti-Rat (Rattus) ELAVL1 Antikörper:
anti-Mouse (Murine) ELAVL1 Antikörper:
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Human Monoclonal ELAVL1 Primary Antibody für ChIP, IP - ABIN577055
Li, Lu, Dai, Torregroza, Hla, Evans: Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1. in Blood 2014
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Human Monoclonal ELAVL1 Primary Antibody für IF, IHC (p) - ABIN560725
Kani, Faca, Hughes, Zhang, Fang, Shahbaba, Luethy, Erde, Schmidt, Pitteri, Zhang, Katz, Gross, Plevritis, McIntosh, Jain, Hanash, Agus, Mallick: Quantitative proteomic profiling identifies protein correlates to EGFR kinase inhibition. in Molecular cancer therapeutics 2012
RNA-binding protein (zeige PTBP1 Antikörper) HuR (HuR) expression negatively correlated with chemokine (CC motif) ligand 5 (CCL5 (zeige CCL5 Antikörper)) expression and macrophage appearance in a cohort of breast tumors.
Data indicate no correlation between RNA-binding protein (zeige PTBP1 Antikörper) HuR intracellular localization in tumor sections and progression free survival.
our research demonstrated that NEAT1 acts as a key regulator in human ovarian carcinogenesis and revealed two regulatory factors (HuR and miR (zeige MLXIP Antikörper)-124-3p) of NEAT1 expression.
The crucial role of HuR as a stabilizing factor for the MR transcript.
study found cytoplasmic HuR is significantly overexpressed in higher-grade (atypical and anaplastic) than in lower-grade meningiomas and the HuR level is correlated with survival in patients with meningioma; siHuR-induced HuR knockdown was shown to reduce the growth of both Ben-Men-1 and IOMM-Lee cells
combined treatments of siHuR and epirubicin significantly reduced the expression of Bcl-2 (zeige BCL2 Antikörper), but increased the expression of Bax (zeige BAX Antikörper), as well as activity and expression levels of caspase-3 (zeige CASP3 Antikörper) and -9. In contrast, overHuR abrogated these effects
High HuR expression is associated with pancreatic ductal adenocarcinomas.
GPRC5A (zeige GPRC5A Antikörper) is a potential oncogene (zeige RAB1A Antikörper) in pancreatic ductal adenocarcinoma cells that is upregulated by gemcitabine with help from HuR.
Hur role in the epithelial-to-mesenchymal transition in pancreatic cancer
exposing glioma cells to the HuR inhibitor tanshinone group compound 15,16-dihydrotanshinone-I or to the newly identified compound 5 disrupts HuR multimerization modules and reduces tumor cell survival and proliferation.
STAU1 (zeige STAU1 Antikörper) & STAU2 & ELAVL1 mRNAs & proteins were detected throughout cow preimplantation development (zeige MTA2 Antikörper) from the germinal vesicle (GV) oocyte to the blastocyst stage; ELAVL2 (zeige ELAVL2 Antikörper) mRNAs were detectable from the GV to the morula stage; ELAVL2 (zeige ELAVL2 Antikörper) protein was in all stages
this study reveals a posttranscriptional regulatory mechanism by which RNA-binding protein (zeige RBM24 Antikörper) Elavl1a regulates embryonic erythropoiesis by maintaining appropriate levels of gata1 (zeige GATA1 Antikörper) expression.
Depletion of CLPABP disturbed the normal subcellular localization of HuR to stress granules, and overexpression of CLPABP induced instability of leptin (zeige LEP Antikörper) mRNA by inhibiting HuR function.
Data (including data from studies using knockout mice or cells from knockout mice) suggest HuR post-transcriptionally regulates Ccr6 (zeige CCR6 Antikörper) expression by binding to and stabilizing Ccr6 (zeige CCR6 Antikörper) mRNA and by promoting Ccr6 (zeige CCR6 Antikörper) translation in helper T-cells; knock-out of HuR reduces Ccr6 (zeige CCR6 Antikörper) expression on helper T-cells, impairs their migration to CNS, and prevents experimental autoimmune encephalomyelitis. (Ccr6 (zeige CCR6 Antikörper) = C-C chemokine receptor type 6 (zeige CCR6 Antikörper))
Taken together, our results indicate that HuR activation is an early event in familial adenomatosis polyposis (FAP (zeige FAP Antikörper))--adenoma but is not present in inflammatory bowel disease (IBD)-dysplasia. Furthermore, our results offer a preclinical proof of concept for HuR inhibition as an effective means of FAP (zeige FAP Antikörper) chemoprevention, with caution advised in the setting of IBD
findings indicate a previously unknown interaction between GSK3beta (zeige GSK3b Antikörper) and ELAV-1 during acute respiratory distress syndrome , and suggest the inhibition of the ELAV-1- GSK3beta (zeige GSK3b Antikörper) pathways as a novel acute respiratory distress syndrome treatment approach.
HuR plays a central role in regulating nuclear import of proteins.
These results indicate that HuR promotes early intestinal mucosal repair after injury by increasing Cdc42 (zeige CDC42 Antikörper) translation.
This study uncovers an anti-sense lncRNA (APOA4 (zeige APOA4 Antikörper)-AS), which is co-expressed with APOA4 (zeige APOA4 Antikörper), and concordantly and specifically regulates APOA4 (zeige APOA4 Antikörper) expression both in vitro and in vivo with the involvement of HuR.
These results suggest that the post-transcriptional regulation of ATX (zeige ENPP2 Antikörper) expression by HuR and AUF1 (zeige HNRNPD Antikörper) modulates cancer cell migration.
Results show that HuR is a key regulator of many genes that make up the molecular signature of activated microglia, including increased production of proinflammatory cytokines, chemokines, and migration-associated factors
Results indicate that HuR induces 14-3-3zeta (zeige YWHAZ Antikörper) translation via interaction with its 3' UTR (zeige UTS2R Antikörper) and that 14-3-3zeta (zeige YWHAZ Antikörper) is necessary for stimulation of intestinal epithelial cell migration after wounding.
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.
ELAV-like protein 1
, Hu antigen R
, embryonic lethal, abnormal vision, drosophila, homolog-like 1
, hu-antigen R
, ELAV like 1
, ELAV-like 1 (Hu antigen R)
, elav-related A
, embryonic lethal, abnormal vision-related A
, ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
, HU-antigen A
, elav-like generic protein