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the direct interaction of AKT2 (zeige AKT2 Proteine) and EF2 was found to be dynamically regulated in embryonic rat cardiomyocytes
These results suggest that binding of eEF2 to the ribosome alters its conformation, resulting in a weakened affinity of eIF5A (zeige EIF5 Proteine) and impairment of this interplay compromises cell growth due to translation elongation defects.
nuclear localization of active eEF-2 depends upon its interaction with p53 (zeige TP53 Proteine), as cells lacking p53 (zeige TP53 Proteine) contain less active eEF-2 in the nuclear compartment
High serum eukaryotic elongation factor 2 level is associated with non-small cell lung cancer.
Results indicated that the eEF2 gene is overexpressed in the majority of several types of cancers and plays an oncogenic role in cancer cell growth.
The expression levels of three putative HA-regulated proteins (TALDO, ANXA1 (zeige ANXA1 Proteine) and EF2) in control, H2O2-, HA- and HA/H2O2-treated OA chondrocytes were verified by Western blotting and the results indeed support the notion that HA acts in anti-oxidation
Data indicate that the accumulation of the cleaved C-terminal small fragment of eukaryotic elongation factor 2 (eEF2) in the nucleus, and C-terminal Src kinase (Csk (zeige CSK Proteine)) could enhance the proteolytic cleavage of eEF2.
Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death.
A single amino acid substitution in eukaryotic elongation factor 2 co-segregates with the disease phenotype of spinocerebellar ataxia 26.
EEF2 phosphorylation by cyclin A (zeige CCNA2 Proteine)-cyclin-dependent kinase 2 (CDK2 (zeige CDK2 Proteine)) on a novel site, serine 595 (S595), directly regulates T56 phosphorylation by eEF2K (zeige EEF2K Proteine).
Myostatin (zeige MSTN Proteine) inhibits eEF2K (zeige EEF2K Proteine)-eEF2 by regulating AMPK (zeige PRKAA1 Proteine) to suppress protein synthesis.
IL-6 (zeige IL6 Proteine) induces the activation of the Stat3 (zeige STAT3 Proteine) signaling and promotes the downmodulation of the p90RSK (zeige RPS6KA1 Proteine)/eEF2 and mTOR (zeige FRAP1 Proteine)/p70S6K (zeige RPS6KB1 Proteine) axes, while it does not affect the activation of AKT (zeige AKT1 Proteine).
AMPKalpha2 (zeige PRKAA2 Proteine) controls cardiac p70S6K (zeige RPS6KB1 Proteine) under normoxia and regulates eEF-2 but not the mTOR (zeige FRAP1 Proteine)-p70S6K (zeige RPS6KB1 Proteine) pathway during ischemia.
The MKK3 (zeige MAP2K3 Proteine)/6-p38gamma (zeige MAPK12 Proteine)/delta pathway mediated an inhibitory phosphorylation of eukaryotic elongation factor 2 (eEF2) kinase, which in turn promoted eEF2 activation (dephosphorylation) and subsequent TNF-alpha (zeige TNF Proteine) elongation.
Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development
induced by basic fibroblast growth factor (zeige FGF2 Proteine) via mitogen-activated protein kinase (zeige MAPK1 Proteine)
eEF-2 is activated by both lithium and GSK-3, whereas, lithium treatment and inhibition of GSK-3 have opposing effects on eEF-2.
eEF-2 phosphorylation has a role in protein synthesis for memory consolidation
A mouse that was mutant for the gene, Dph4 (zeige DNAJC24 Proteine), was identified.
Eukaryotic elongation factor-2 (eEF2) may be a limiting factor in milk protein (zeige CSN2 Proteine) synthesis (Review)
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation.
eukaryotic translation elongation factor 2
, elongation factor 2-like
, elongation factor 2
, polypeptidyl-tRNA translocase
, elongation factor-2