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Thyroid stimulating hormone activates CRTC2 via the TSHR (zeige TSHR ELISA Kits)/cAMP/PKA pathway.
CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in transplant recipients after solid organ transplantation.
CRTC2 strongly enhances GR-induced transcriptional activity of glucocorticoid-responsive genes.
Our results establish a role for CRTC2 as a lymphoma tumor suppressor gene
the high expression of CRTC2 and PROM1 may play an important role in the occurrence and hereditary, and also advance the potential pathways that integrate genetic variants in the development of NSCLC.
The data from the current study demonstrated novel PROM1 and CRTC2 mutations, which could promote lung cancer development.
These results clearly indicate that non-phosphorylated CRTC2 strongly enhances hepatitis b virus biosynthesis through inducing PGC1alpha expression.
Phosphorylation of CRTC2 at its AMPK (zeige PRKAA1 ELISA Kits) target site, Ser (zeige SIGLEC1 ELISA Kits) 171, dictated its subcellular localization, and the activation of aromatase (zeige CYP19A1 ELISA Kits) PII in preadipocytes.
CRTC2 enhances CREB (zeige CREB1 ELISA Kits) phosphorylation through an association with the protein arginine methyltransferase 5 (PRMT5 (zeige PRMT5 ELISA Kits)).
Mechanism of CREB (zeige CREB1 ELISA Kits) recognition and coactivation by the CREB (zeige CREB1 ELISA Kits)-regulated transcriptional coactivator CRTC2
the existence of an unusual functional interplay between STATs and CREB (zeige CREB1 ELISA Kits) at the onset of adipogenesis through shared CRTC cofactors, is reported.
CRTC2 play a role in hepatic cholesterol synthesis through SREBP-2 (zeige SREBF2 ELISA Kits).
Catecholaminergic deletion of Rictor (zeige RICTOR ELISA Kits) increases water, sucrose, and morphine intake but not preference in a two-bottle choice assay in stress-naive mice, and these effects are maintained after stress. Ventral Tegmental Area-specific knockout of Rictor (zeige RICTOR ELISA Kits) increases water and sucrose intake after physical CSDS, but does not alter consummatory behavior in the absence of stress.
Three mouse CRTCs (Crtc1 (zeige CRTC1 ELISA Kits), Crtc2 and Crtc3 (zeige CRTC3 ELISA Kits)) exhibit distinct patterns of 14-3-3 (zeige YWHAQ ELISA Kits) binding at three conserved sites corresponding to S70, S171 (zeige NUMB ELISA Kits), and S275 (in CRTC2).
the protein expression of adipose tissue CRTC 2 was reduced in mice with a combined application of change to general diet and exercise. In addition, while the protein expressions of lipase (zeige LIPG ELISA Kits) ATGL (zeige PNPLA2 ELISA Kits) and HSL (zeige LIPE ELISA Kits) were reduced in the mice fed with the high fat diet continually after obesity was induced
CRTC2 promotes Th17 cell differentiation via stimulation of IL-17A (zeige IL17A ELISA Kits) and IL-17F (zeige IL17F ELISA Kits) expression by binding to CREB (zeige CREB1 ELISA Kits) over both promoters. CRTC2-mutant mice have decreased Th17 cells, and they are protected from experimental autoimmune encephalitis.
chronic increases in CRTC2 activity in the liver are indeed sufficient to promote hepatic insulin (zeige INS ELISA Kits) resistance and to disrupt glucose homeostasis
cAMP, SIK (zeige SIK1 ELISA Kits) and CRTC mediate StAR expression through activation of individual StAR gene loci.
RICTOR (zeige RICTOR ELISA Kits)/mTORC2 is important for interactions between vasculature, adipocytes, and brain to tune physiological outcomes, such as blood pressure and locomotor activity.
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.
CREB regulated transcription coactivator 2
, CREB-regulated transcription coactivator 2
, CREB-regulated transcription coactivator 2-like
, transducer of regulated cAMP response element-binding protein (CREB) 2
, transducer of CREB protein 2
, transducer of regulated cAMP response element-binding protein 2