Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Proteine (KLRK1)

Bezeichnung:
Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Proteine (KLRK1)
Auf www.antikoerper-online.de finden Sie aktuell 21 Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Antikörper (206) und Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 238 Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Produkte verfügbar.
Synonyme:
CD314, D6H12S2489E, D12S2489E, KLR, KLRK1, NKG2-D, Nkg2d, Nkrp2
alle Proteine anzeigen Gen GeneID UniProt
KLRK1 22914 P26718
KLRK1 27007 O54709
KLRK1 24934 O70215

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Am meisten referenzierte Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Proteine

  1. Human KLRK1 Protein expressed in Escherichia coli (E. coli) - ABIN1098706 : Guerra, Tan, Joncker, Choy, Gallardo, Xiong, Knoblaugh, Cado, Greenberg, Greenberg, Raulet: NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. in Immunity 2008 (PubMed)
    Zeige alle 2 Referenzen für 1098706

  2. Human KLRK1 Protein expressed in CHO Cells - ABIN2003085 : Houchins, Yabe, McSherry, Bach: DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. in The Journal of experimental medicine 1991 (PubMed)

Weitere Proteine zu Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Interaktionspartnern

Human Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) Interaktionspartner

  1. this study shows that CD20 (zeige MS4A1 Proteine)-specific immunoligands engaging NKG2D enhance gammadelta T cell-mediated lysis of lymphoma cells

  2. High NKG2D expression is associated with gastric cancer.

  3. Supporting a role for NKG2D ligand expression in controlling the progression of early-stage B cell lymphomas in humans, we found higher expression of a microRNA that inhibits human NKG2D ligand expression in tumor cells from high-grade compared with low-grade follicular lymphoma patients.

  4. On-treatment decrease of NKG2D correlates to early emergence of clinically evident hepatocellular carcinoma after interferon (zeige IFNA Proteine)-free therapy for chronic hepatitis C

  5. The interaction of Fas receptor (zeige FAS Proteine) with FasL (zeige FASL Proteine) leads to an activation of the Tag7 (zeige PGLYRP1 Proteine)-Hsp70 (zeige HSP70 Proteine) complex in the lymphocyte membrane fraction, and here FasL (zeige FASL Proteine) acts as a receptor that induces intracellular signaling in lymphocytes.An interaction of the MicA (zeige MICA Proteine) stress ligand with the NKG2D receptor is necessary for the release of this cytotoxic complex

  6. Blockade of NKG2D on CD8 (zeige CD8A Proteine)(+) T cells inhibited the migration over ligand-expressing endothelial cells. Intestinal induction of NKG2D ligands and ligand-induced down-regulation of NKG2D in Crohn's disease (CD) suggest that the NKG2D-ligand interaction may be involved in both the activation and recruitment of NKG2D(+) lymphocytes into the inflamed CD intestine.

  7. IDH mutant glioma cells acquire resistance to natural killer cells through epigenetic silencing of NKG2D ligands ULBP1 and ULBP3

  8. non-virally infected human T cells can express NKG2DL, with implications for stress surveillance by the large number of NKG2D-expressing NK cells sequestered in the liver.

  9. After PSK (zeige TAOK2 Proteine) administration, INF (zeige GIF Proteine)-g production in CD8 (zeige CD8A Proteine)(+) T cells increased in mice with cells expressing neither Rae-1 (zeige RAE1 Proteine) nor H60, but did not change in mice implanted with cells expressing both Rae-1 (zeige RAE1 Proteine) and H60. We demonstrated that the expression of NKG2DLs affects tumor immunity and the efficacy of immuno therapy in tumor-bearing mouse model

  10. These results suggest the involvement of HIV-1 nef and human NKG2D-NKG2D ligand interactions in the enhanced susceptibility of HIV-1-infected cells from HIV elite controllers to antibody-dependent cellular cytotoxicity responses.

Mouse (Murine) Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) Interaktionspartner

  1. proposed that TLR9 (zeige TLR9 Proteine) regulates the NF-kappaB (zeige NFKB1 Proteine)-NLRP3 (zeige NLRP3 Proteine)-IL-1beta (zeige IL1B Proteine) pathway negatively in Salmonella-induced NKG2D-mediated intestinal inflammation and plays a critical role in defense against S. typhimurium infection and in the protection of intestinal integrity.

  2. NKG2D-deficient mice and mice constitutively expressing NKG2D ligands had increased incidence of B cell tumors, confirming that the inability to clear NKG2D ligand-expressing cells was important in tumor suppression and that NKG2D ligand expression is a marker of nascent tumors

  3. data show that NKG2D has a nonredundant role in priming of CD8 (zeige CD8A Proteine)(+) T cells to produce antiviral cytokines

  4. NKG2D augments Ly49H-dependent proliferation of NK cells; however, NKG2D signaling alone is inadequate for expansion of NK cells, likely due to only transient expression of the NKG2D-DAP12 (zeige TYROBP Proteine) complex

  5. The elevated cytotoxicity achieved by suppressing mTOR (zeige FRAP1 Proteine) was a result of up-regulation of NKG2D and TNF-alpha (zeige TNF Proteine). The inhibition of STAT5 (zeige STAT5A Proteine) pathways via siRNA interference or a specific inhibitor eliminated the up-regulation of NKG2D and TNF-alpha (zeige TNF Proteine) in rapamycin-treated Vgamma4 gammadelta T cells.

  6. study demonstrates that the effect of NKG2D on B1a cell development occurs at a developmental stage that precedes the common lymphoid progenitor; findings reveal an unexpected new role for NKG2D in the regulation of B1a cell development

  7. Sirt6 (zeige SIRT6 Proteine) binds to promoters of NKG2D ligand genes and regulates the H3K9 and H3K56 acetylation levels

  8. These results support the conclusion that svH1C mimics Neu5Ac-containing sequences and interacts with cell-surface receptor NKG2D, which contains a lectin-like domain

  9. These results indicate that, unlike in the pancreas, NKG2D-NKG2D ligand interaction does not play a critical role in obesity-induced inflammation in the adipose tissue.

  10. The results show that NK cells and the NKG2D receptor play a role in control of lymphomas, and that selection of NKG2D-ligand (MULT1 (zeige ULBP1 Proteine)) loss mutants provides a mechanism for tumor escape.

Pig (Porcine) Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) Interaktionspartner

  1. The effect of Bacillus cereus on the stress response of enterocytes, including the expression of NKG2D, is reported.

Rhesus Monkey Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) Interaktionspartner

  1. Determined expressions of NKG2D in decidual natural killer cells in patients having spontaneous abortions.

Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) Protein Überblick

Protein Überblick

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.

Alternative names and synonyms associated with Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1)

  • killer cell lectin-like receptor subfamily K, member 1 (KLRK1)
  • NKG2-D type II integral membrane protein-like (LOC100398970)
  • killer cell lectin-like receptor subfamily K, member 1 (Klrk1)
  • NKG2D protein (NKG2D)
  • CD314 Protein
  • D6H12S2489E Protein
  • D12S2489E Protein
  • KLR Protein
  • KLRK1 Protein
  • NKG2-D Protein
  • Nkg2d Protein
  • Nkrp2 Protein

Bezeichner auf Proteinebene für KLRK1

killer cell lectin-like receptor subfamily K, member 1 , NKG2-D type II integral membrane protein-like , NK cell receptor D , NKG2-D type II integral membrane protein , NKG2-D-activating NK receptor , natural killer cell group 2D , NK lectin-like receptor , NKLLR , NKR-P2, ortholog of human NKG2D , killer cell lectin-like receptor subfamily K member 1 , NKG2-D activating NK receptor

GENE ID SPEZIES
611355 Canis lupus familiaris
100126736 Papio anubis
100398970 Callithrix jacchus
22914 Homo sapiens
27007 Mus musculus
24934 Rattus norvegicus
396737 Sus scrofa
450153 Pan troglodytes
574240 Macaca mulatta
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