anti-Huhn Heat Shock 60kDa Protein 1 (Chaperonin) Antikörper für Western Blotting

Recommended Heat Shock 60kDa Protein 1 (Chaperonin) Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) Antikörper
  • 12
  • BP5
  • CG12101
  • Cpn60
  • Dmel\\CG12101
  • Dmhsp60
  • G62
  • HSP60
  • HSP60A
  • Hsp60A
  • IEF16
  • Mmp-P1
  • SSP 7506
  • cpn60
  • d-hsp60
  • hsp60
  • hsp60A
  • l(1)10Ac
  • l(1)BP5
  • l(1)G8
  • l(1)HM21
  • l(1)L12
  • l(1)dp025
  • HSPD1
  • hld4
  • groel
  • hsp65
  • spg13
  • chaperonin
  • CPN60
  • MIF4
  • MNA2
  • mopA
  • groL
  • crpA
  • cb863
  • fa04a05
  • fb22d10
  • fi27b05
  • id:ibd2197
  • sb:cb144
  • wu:fa04a05
  • wu:fb22d10
  • wu:fi04a12
  • wu:fi27b05
  • GROEL
  • HLD4
  • HSP-60
  • HSP65
  • HuCHA60
  • SPG13
  • 60kDa
  • Hsp60
  • Hspd1-30p
  • Heat shock protein 60
  • heat shock 60kDa protein 1 (chaperonin)
  • chaperone ATPase HSP60
  • molecular chaperone GroEL
  • chaperonin GroEL
  • mitochondrial chaperonin
  • heat shock protein 60
  • heat shock 60kD protein 1 (chaperonin)
  • heat shock protein 1 (chaperonin)
  • Hsp60
  • HSPD1
  • hspd1
  • HSP60
  • groEL
  • hsp60
  • groEl
  • Hspd1
Reaktivität
Huhn, Human, Ratte (Rattus)
652
436
417
270
245
227
220
205
176
167
139
117
116
96
94
67
42
41
36
36
22
21
21
21
19
19
18
17
17
4
4
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Wirt
Maus
421
280
9
Klonalität
Monoklonal
Konjugat
Unkonjugiert
26
19
18
17
14
12
11
11
11
11
11
10
10
9
9
9
9
9
8
8
8
8
8
8
8
8
8
8
4
4
4
4
3
Applikation
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
622
289
288
278
266
261
197
187
84
13
12
10
8
7
5
2
2
1
1
Hersteller
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Bilder

Produktnummer ABIN1107605
$ 313.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
3.1229854 ABIN361786 FACS IHC WB Mouse IgG1 Anmelden zum Anzeigen LK2 16
3.1229854 ABIN2481441 FACS IP IHC ELISA WB PE-Atto 594 Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481444 FACS IP IHC ELISA WB Streptavidin Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481440 FACS IP IHC ELISA WB HRP Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481431 FACS IP IHC ELISA WB Atto 594 Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481435 FACS IP IHC ELISA WB Atto 700 Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481428 FACS IP IHC ELISA WB Atto 390 Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481429 FACS IP IHC ELISA WB Atto 488 Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481432 FACS IP IHC ELISA WB Atto 633 Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481433 FACS IP IHC ELISA WB Atto 655 Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481434 FACS IP IHC ELISA WB Atto 680 Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481438 FACS IP IHC ELISA WB Biotin Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481439 FACS IP IHC ELISA WB FITC Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481436 FACS IP IHC ELISA WB Alkaline Phosphatase (AP) Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481430 FACS IP IHC ELISA WB Atto 565 Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481437 FACS IP IHC ELISA WB APC Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481442 FACS IP IHC ELISA WB PerCP Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2481443 FACS IP IHC ELISA WB PE Mouse IgG1 Anmelden zum Anzeigen LK1 2
3.1229854 ABIN2486161 IP IHC ELISA WB PE-Atto 594 Rabbit Anmelden zum Anzeigen Polyclonal 12
3.1229854 ABIN2486160 IP IHC ELISA WB HRP Rabbit Anmelden zum Anzeigen Polyclonal 12

General

Antigen Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) Antikörper
Reaktivität Huhn, Human, Ratte (Rattus)
(652), (436), (417), (270), (245), (227), (220), (205), (176), (167), (139), (117), (116), (96), (94), (67), (42), (41), (36), (36), (22), (21), (21), (21), (19), (19), (18), (17), (17), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Wirt Maus
(421), (280), (9)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Unkonjugiert
(26), (19), (18), (17), (14), (12), (11), (11), (11), (11), (11), (10), (10), (9), (9), (9), (9), (9), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (4), (4), (4), (4), (3)
Applikation Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(622), (289), (288), (278), (266), (261), (197), (187), (84), (13), (12), (10), (8), (7), (5), (2), (2), (1), (1)
Pubmed 3 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Referenzen Bilder
Spezifität This antibody reacts to HSP60.
Reinigung Affinity chromatography
Immunogen Recombinant human heat shock protein 60 (HSP60)
Klon SJ-60
Isotyp IgG1

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben
Antigen
Andere Bezeichnung HSP60 (HSPD1 Antibody Abstract)
Hintergrund Heat shock 60KD protein (HSP60) is a member of the chaperonin class of protein factors, which include the Escherichia coli groEL protein and the Rubisco subunit-binding protein of chloroplasts. It acts as a costimulator of human regulatory CD4-positive/CD25 -positive T cells, which inhibit lymphoproliferation and IFNG and TNFsecretion by CD4-positive and CD8-positive T cells. HSP60 enhances Treg activity via TLR2, leading to activation of an intracellular signaling cascade that included p38, as well as inhibition of ERK phosphorylation. Suppression of target T cells is mediated by both cell-to-cell contact and by secretion of TGFB and IL10, and it leads to downregulation of ERK, NFKB, and TBET expression. The self-molecule HSP60 can downregulate adaptive immune responses by upregulating Tregs through TLR2 signaling.Synonyms: 60 kDa chaperonin, 60 kDa heat shock protein mitochondrial, CPN60, Chaperonin 60, GROEL, GroEL Homolog, HSP-60, HSPD1, Heat shock protein 60, HuCHA60, Mitochondrial matrix protein P1, P60 lymphocyte protein
Gen-ID 3329
NCBI Accession NP_002147
UniProt P10809
Forschungsgebiet Heat Shock Proteins
Pathways Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben
Rekonstitution Restore with 1.2 % sodium acetate or neutral PBS
Konzentration 0,1 mg/mL
Buffer 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung -20 °C
Informationen zur Lagerung Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen

Produktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Zanin-Zhorov, Cahalon, Tal, Margalit, Lider, Cohen: "Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling." in: The Journal of clinical investigation, Vol. 116, Issue 7, pp. 2022-32, 2006

Hansen, Bross, Westergaard, Nielsen, Eiberg, Børglum, Mogensen, Kristiansen, Bolund, Gregersen: "Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter." in: Human genetics, Vol. 112, Issue 1, pp. 71-7, 2002

Cheng, Hartl, Martin, Pollock, Kalousek, Neupert, Hallberg, Hallberg, Horwich: "Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria." in: Nature, Vol. 337, Issue 6208, pp. 620-5, 1989

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) antibody (ABIN1107605) anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) antibody
Western Blotting (WB) image for anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) antibody (ABIN1107605) anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) antibody (Image 2)