anti-Maus DDX58 Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended DDX58 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) Antikörper
  • RIG-I
  • RIGI
  • RLR-1
  • 6430573D20Rik
  • C330021E21
  • RHIV-1
  • RIG-1
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
  • DDX58
  • Ddx58
Reaktivität
Human, Maus, Ratte (Rattus)
168
89
30
21
17
3
2
Wirt
Kaninchen
116
47
9
6
Klonalität
Polyklonal
Konjugat
Dieser DDX58 Antikörper ist unkonjugiert
12
8
6
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
131
57
45
40
26
12
11
5
5
4
3
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN730663
$ 295.90
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2812304 IF (p) Alexa Fluor 594 Rabbit IgG pThr170 Anmelden zum Anzeigen Polyclonal
1 ABIN2812302 IF (p) Alexa Fluor 594 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN757811 IF (p) Cy5 Rabbit IgG pThr170 Anmelden zum Anzeigen Polyclonal
1 ABIN757812 IF (p) Cy5.5 Rabbit IgG pThr170 Anmelden zum Anzeigen Polyclonal
1 ABIN757813 IF (p) Cy7 Rabbit IgG pThr170 Anmelden zum Anzeigen Polyclonal
1 ABIN757810 IF (p) Cy3 Rabbit IgG pThr170 Anmelden zum Anzeigen Polyclonal
1 ABIN757814 IF (p) FITC Rabbit IgG pThr170 Anmelden zum Anzeigen Polyclonal
1 ABIN730667 IF (p) Cy5 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN730669 IF (p) Cy7 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN730668 IF (p) Cy5.5 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN730670 IF (p) FITC Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN730666 IF (p) Cy3 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN877551 IF (p) Alexa Fluor 555 Rabbit IgG pThr170 Anmelden zum Anzeigen Polyclonal
1 ABIN877553 IF (p) Alexa Fluor 350 Rabbit IgG pThr170 Anmelden zum Anzeigen Polyclonal
1 ABIN877555 IF (p) Alexa Fluor 488 Rabbit IgG pThr170 Anmelden zum Anzeigen Polyclonal
1 ABIN877554 IF (p) Alexa Fluor 647 Rabbit IgG pThr170 Anmelden zum Anzeigen Polyclonal
1 ABIN893759 IF (p) Alexa Fluor 647 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN893762 IF (p) Alexa Fluor 555 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN893760 IF (p) Alexa Fluor 350 Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN893763 IF (p) Alexa Fluor 488 Rabbit IgG Anmelden zum Anzeigen Polyclonal

General

Antigen DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) Antikörper
Reaktivität Human, Maus, Ratte (Rattus)
(168), (89), (30), (21), (17), (3), (2)
Wirt Kaninchen
(116), (47), (9), (6)
Klonalität
Polyklonal
Konjugat Dieser DDX58 Antikörper ist unkonjugiert
(12), (8), (6), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(131), (57), (45), (40), (26), (12), (11), (5), (5), (4), (3), (2), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-DDX58 Antikörper

Target Details DDX58 Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human DDX58
Isotyp IgG

Target Details DDX58

Produktdetails anti-DDX58 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung DDX58 (DDX58 Antibody Abstract)
Hintergrund

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs), IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.

Subcellular location: Cytoplasm

Synonyms: RIGI, RIG-I, RLR-1, SGMRT2, Probable ATP-dependent RNA helicase DDX58, DEAD box protein 58, RIG-I-like receptor 1, Retinoic acid-inducible gene 1 protein, RIG-1, Retinoic acid-inducible gene I protein, DDX58

Gen-ID 23586
UniProt O95786
Forschungsgebiet Immunology, Chromatin Binding Proteins, DNA/RNA, Transcription Factors
Pathways Activation of Innate immune Response, Hepatitis C

Anwendungsinformationen

Produktdetails anti-DDX58 Antikörper Target Details DDX58 Handhabung Bilder zurück nach oben
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-DDX58 Antikörper Target Details DDX58 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Bilder

Produktdetails anti-DDX58 Antikörper Target Details DDX58 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) antibody (ABIN730663) anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) antibody
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) antibody (ABIN730663) anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) antibody (Image 2)